参麦注射液防治女性乳腺癌FAC方案心脏毒性临床研究  

Clinical Observation of Cardiac Toxicity Induced by FAC Regimen in Female Breast Cancer Treated by Shenmai Injection

作　　者：刘琦[1] 张新峰 程旭锋[3] 王伟[3] 赵慧朵[3] 

机构地区：[1]河南中医学院,河南郑州450046 [2]郑州大学附属肿瘤医院,河南郑州450008 [3]河南中医学院第一附属医院,河南郑州450000

出　　处：《中医学报》2014年第8期1090-1091,1094,共3页Acta Chinese Medicine

基　　金：河南省科技厅2011年科技攻关项目(编号:112102310108);河南省科技厅2010年基础与前沿项目(编号:102300410040)

摘　　要：目的:探讨参麦注射液对乳腺癌FAC化疗方案心脏毒性的防治作用。方法:42例乳腺癌患者随机分为对照组和参麦组,对照组单用FAC方案化疗,参麦组在化疗同时使用参麦注射液,观察两组患者化疗前后的心电图(ECG)、心功能、心功能异常发生率、肌钙蛋白T(cTnT)浓度及左室射血分数(LVEF)的变化情况。结果:参麦组患者的心电图异常改变发生率、心功能异常发生率、外周血中cTnT浓度均低于对照组(P<0.05),且LVEF高于对照组(P<0.05)。结论:参麦注射液可用于FAC化疗方案心脏毒性的防治。Objective ： To explore the control effects of cardiac toxicity induced by FAC regimen in female breast cancer treated by Shen- mai injection. Methods ：42 patients with breast cancer were randomly divided into the control group and the shenmai group. The control group only received chemotherapy by FAC regimen. The shenmai group received chemotherapy and Shenmai injection. Electrocardiogram （ECG） ,cardiac function, the incidence of cardiac function abnormality, change of cTnT and LVEF were observed before and after chemotherapy. Result：The incidence of electrocardiogram（ECG） abnormality, the incidence of cardiac function abnormality, cTnT con- centration in Shenmai group were lower than control group（P 〈0.05 ,P 〈0.01 ） ,and the LVEF level were higher than control group （P 〈 0.05）. Conclusion ： Shenmai injection could be used in the control of cardiac toxicity by FAC regimen.

关 键 词：乳腺癌 参麦注射液 FAC方案 心脏毒性 

分 类 号：R273.79[医药卫生—中西医结合]