加味青娥丸治疗早期股骨头缺血性坏死临床研究  

Clinical Research on Flavored Qing'e Pill Treatment of Early Ischemic Necrosis of Femoral Head

作　　者：徐麒 何强 

机构地区：[1]巴中市中医医院,四川巴中636000

出　　处：《中医学报》2014年第8期1144-1146,共3页Acta Chinese Medicine

基　　金：四川省中医药管理局重点科研项目(编号:2004A41)

摘　　要：目的:观察加味青娥丸治疗早期股骨头缺血性坏死(INFH)的临床疗效。方法:将130例患者(共157髋)按照随机数字表法分为观察组和对照组,每组各65例。对照组给予常规治疗加钙尔奇D治疗,观察组在常规治疗基础上加用加味青娥丸治疗。随访半年,观察并比较两组患者治疗前后骨髓水肿、关节疼痛VAS评分、关节功能Harris评分和血清脂联素、TNF-α、CRP、NO水平的变化。结果:1观察组治疗前骨髓水肿率为76.3%,对照组治疗前骨髓水肿率为78.0%,两组比较差异无统计学意义(P>0.05)。治疗后观察组骨髓水肿率为56.3%,对照组骨髓水肿率为74.1%,观察组明显低于治疗前和对照组治疗后,差异有统计学意义(P<0.05),对照组治疗前后比较差异无统计学意义(P>0.05);2在VAS评分和Harris评分方面:治疗前两组间差异无统计学意义(P>0.05),对照组治疗前后比较差异无统计学意义(P>0.05),观察组治疗后VAS评分明显低于治疗前和对照组治疗后,Harris评分明显高于治疗前和对照组治疗后,差异有统计学意义(P<0.05);3在血清脂联素、TNF-α、CRP、NO方面,治疗前两组间差异无统计学意义(P>0.05);对照组治疗前后比较差异无统计学意义(P>0.05);观察组治疗后血清脂联素水平明显高于治疗前和对照组治疗后,TNF-α、CRP、NO水平明显低于治疗前和对照组治疗后,差异有统计学意义(P<0.05)。结论:加味青娥丸治疗早期INFH可以通过调整患者体内相关因子水平,有效缓解骨髓水肿,减轻临床症状,改善关节功能,提高生存质量。Objective：To explore the the clinical effect of early ischemic necrosis of femoral head （INFH） treated by flavored Qing＇e Pill. Methods ：130 eases of patients with INFH（ 157 hips） were randomly divided into the observation group and the control group（ n = 65 ）. the Control group was given conventional treatment and Caltrate D,and the observation group was treated with conventional therapy and flavored Qing＇e Pill. Follow-up for half of a year, observed and compared the bone marrow edema,joint pain VAS seores ,joint function Harris score and serum level change of adiponeetin and TNF-α, CIRP,NO of the two groups before and after treatmenl. Results：（1） The rate of bone marrow edema of the observation group and the control group before treatment respectively were 76.3% and 78.0% respectively,there was no statistically significant difference（ P 〉 0.05 ） ; bone marrow edema rate of the two groups after treatment re- spectively were 56.3% and 74.1% respec.tively,and the observation group was lower than that of before treatment and the control group after treatment,the difference has statistically significant（ P 〈 0.05 ） ;the difference has no statistical significance of the control group betbre and after treatment（ P 〉0.05）. （2） In the aspects of VAS score and the Harris score ：there was no stafistieally signifieant dift）erene.e between the two groups before treatment （P 〉 0.05） ;the difference has no statistical significance of the control group betbre and alter treatment（P 〉 0.05 ） ;the VAS score of the observation group after treatment was significantly lower than that of before treatment and the eontrol group after treatment, Harris score were significantly higher than that of before treatment and the control group after treatment（ P 〈0.05 ）. （3）In the aspects of serum level of adiponeetin ,TNF-α ,CRP and NO, there was no statistically significant difference between the two groups before treatment（ P 〉 0.05 ） ;the difference has no sta

关 键 词：股骨头缺血性坏死 加味青娥丸 钙尔奇D 骨髓水肿 脂联素 

分 类 号：R274.818[医药卫生—中医骨伤科学]