TGF-β通过不同机制对肿瘤侵袭转移影响的研究述评  

Study on Transforming Growth Factor-β Affecting Tumor Progression by Different Mechanisms

作　　者：倪露露[1,2] 杨佳[1,2] 骆莹滨 李赛凯 李雁[1] 

机构地区：[1]上海中医药大学附属上海市中医医院肿瘤科,上海200071 [2]上海中医药大学,上海201203

出　　处：《辽宁中医杂志》2014年第8期1606-1608,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：上海市自然科学基金项目(111402)

摘　　要：转化生长因子-β(TGF-β)是一种分泌性多肽,在调控细胞周期,参与调节细胞的增殖、分化、发育和凋亡等方面起着重要作用,它的信号经由受体丝氨酸苏氨酸激酶以及细胞内Smad效应器而发生作用。TGF-β与多种疾病,尤其是肿瘤的发生发展密切相关,在各种细胞类型中,TGF-β抑制增殖,诱导细胞凋亡。TGF-β超家族与其相应的受体,组成一个影响肿瘤发生和发展的信号通路,在血管生成,免疫及细胞外微环境方面起了重要的作用。此外在肿瘤进展的末期,TGF-β经由免疫系统的抑制而促进肿瘤发生,改变上皮肿瘤细胞的分化,促成上皮-间质转化(epithelial-mesenchymal transition,EMT)的形成,促进肿瘤的侵袭转移。As a secreted polypeptide, transforming growth factor - β （TGF - β） has important roles in cell - cycle control and resulating cell proliferation, differentiation, development and angiogenesis, and that signals via receptor serine/threonine kinases and intracellular Smad effectors. TGF -β is connected to many diseases, especially to the occurrence and development of tumor. TGF -β inhibits proliferation and induces apoptosis in various cell types. TGF -β super family and the related receptors, composing a signal pathway that impacts carcinogenesis, play an important part in the angiogenesis,immunization and the extracellular microenvironment. And at late stages of tumor progression, TGF -β promotes tumorigenesis via suppression of the immune system and changes in cell differentiation of epithelial tumor cells, favouring the formation of EMT, and then promotes tumor inva- sion and metastasis.

关 键 词：TGF-Β SMADS蛋白 肿瘤的侵袭和转移 EMT 

分 类 号：R273[医药卫生—中西医结合]