益艾康胶囊对无症状期HIV感染者T淋巴细胞亚群的影响  

The effect of Yiaikang capsules on T lymphocyte subsets of asymptomatic HIV infected patients

作　　者：刘萍萍[1] 李倩如[1] 轩小燕[1] 董子明[2] 王哲 杜英[1] 

机构地区：[1]郑州大学基础医学院微生物学与免疫学教研室,郑州450001 [2]郑州大学基础医学院病理生理学教研室,郑州450001 [3]河南省疾病控制中心性病艾滋病研究所,郑州450016

出　　处：《重庆医学》2014年第22期2853-2854,2858,共3页Chongqing medicine

基　　金：河南省医学科技攻关项目(2011010016);河南省医学科技攻关项目(2011020079)

摘　　要：目的探讨益艾康胶囊对无症状期HIV感染者淋巴细胞亚群的影响。方法采用流式细胞术对益艾康胶囊干预组和对照组患者进行外周静脉血T淋巴细胞计数,并检测各T淋巴细胞亚群百分率。结果益艾康胶囊干预组患者静脉血CD4+、CD4+CD45RA+、CD4+CD45RO+、CD4+CD28+、CD4+CD95+T细胞比例均显著高于对照组(P<0.05);而CD8+、CD8+CD38+T细胞比例显著低于对照组(P<0.05)。结论益艾康胶囊能有效减缓无症状期HIV感染者CD4+T淋巴细胞亚群的减少。Objective To explore the effect of Yiaikang capsule on T lymphocyte subsets of asymptomatic HIV infected pa-tients ,and look for sensitive indicator which can reflect the therapeutic effect of HIV drug .Methods Peripheral venous blood sam-ples were collected from Yiaikang capsule treated and untreated asymptomatic HIV infected patients .Flow cytometry was used to detect T lymphocyte count and the T lymphocyte subsets percentage in the venous blood .Results The percentages of CD4＋ ,CD4＋CD45RA＋ ,CD4＋CD45RO＋ ,CD4＋ CD28＋ ,and CD4＋ CD95＋ T cells in Yiaikang treatment group were significantly higher than that of control group（P〈0 .05） ,while the percentages of CD8＋ ,CD8＋CD38＋ T cells were significantly lower than that of control group（P〈0 .05） .Conclusion Yiaikang capsule can effectively slow the decrease of CD4＋ T lymphocyte subgroup in asymptomatic HIV infected patients and promote the activation of CD 4＋ T lymphocytes .

关 键 词：益艾康胶囊 T淋巴细胞亚群 

分 类 号：R259[医药卫生—中西医结合]