TGF-β_1/smads信号转导通路在IPF病程中的作用初探  

Role of TGF β_1/Smads Signal Transduction Pathway in Course of IPF

作　　者：袁佺[1] 庞立健[2] 臧凝子[1] 刘创[1] 滑震 吕晓东[2] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医药大学学报》2014年第8期97-100,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然基金面上项目(81373579);十二五国家中医药管理局中医络病重点学科建设项目;辽宁省科学计划项目(2012020108-202);辽宁省中医临床重点学(专)科服务能力建设项目(2013-lnzyxzk-02)

摘　　要：特发性肺间质纤维化为一种严重的呼吸系统疾病,其特点主要为慢性、弥漫性、进行性以及限制性通气功能障碍,该病病因复杂且预后较差,目前尚缺乏安全有效的治疗方案。近年来,细胞因子网络在IPF发生、进展过程中的作用越发受到重视,其中TGF-β1为目前研究最多、公认的重要因素。该文简单叙述IPF的分子机制、TGF-β1/smads信号转导通路的作用途径,并对其致IPF的病理作用给出较为详尽的解答。Idiopathic pulmonary fibrosis a serious respiratory disease. Its characteristics is chronic, diffuse, progressive and lung restrictive ventilatory dysfunction. The cause of it is complexed and prognosis is poor. So far, we have no safe and effective treatment to treat it. Recently, during the progress of IPF, the functions of cytokine network is more and more realized. As one of them, TGF- β1 is the most studied and accepted factor. The artical briefly describes the molecular mechanism of IPF and the function pathway of TGF- β1/smads. At the same time, we expound the pathological role of it detailedly.

关 键 词：转化生长因子Β1 SMADS 信号转导通路 肺间质纤维化 

分 类 号：R563[医药卫生—呼吸系统]