苯海拉明软膏中盐酸苯海拉明的含量测定  

Content determination of diphenhydramine hydrochloride in diphenhydramine ointment

作　　者：余晓霞[1] 施玉旋[1] 朱桦[1] 

机构地区：[1]中山大学孙逸仙纪念医院药学部,510120

出　　处：《中国实用医药》2014年第22期3-4,共2页China Practical Medicine

摘　　要：目的建立苯海拉明软膏中盐酸苯海拉明的含量测定方法。方法比较铬酸钾指示剂法和酸碱滴定法的线性、精密度和回收率。结果铬酸钾指示剂法中,盐酸苯海拉明在3.99～19.94 mg/ml范围内有良好的线性关系,r=0.9999;平均回收率为97.15%,RSD为1.59%。酸碱滴定法中盐酸苯海拉明在4.06～20.32 mg/ml范围呈现良好的线性关系,r=0.9993;平均回收率为98.90%,RSD=0.84%。结论酸碱滴定法准确、可靠,可用于苯海拉明软膏中盐酸苯海拉明的含量测定。Objective To establish a method to determine the contents of diphenhydramine hydrochloride in diphenhydramine ointment. Methods Linearity, precision and recovery between potassium chromate indicator method and acid-base titration method were compared. Results By potassium chromate indicator method, diphenhydramine hydrochloride yielded a linear range of 3.99~19.94 mg/ml （r=0.9999）, with the average recovery of 97.15%and RSD of 1.59%. By acid-base titration, determination of diphenhydramine hydrochloride yielded a linear range of 4.06~20.32 mg/ml （r=0.9993）, with the average recovery of 98.90%and RSD of 0.84%. Conclusion Acid-base titration method is accurate, reliable, and can be used for content determination of diphenhydramine hydrochloride in diphenhydramine ointment.

关 键 词：苯海拉明软膏 盐酸苯海拉明 容量分析法 含量测定 

分 类 号：R927.2[医药卫生—药学]