瘦素受体基因Gln223Arg多态性与高血压患病风险的meta分析  

Association of leptin receptor gene Gln223Arg polymorphism with hypertension risk——a meta analysis

作　　者：刘兵兵[1] 赵静[2] 冯玲[1] 李增宁[1] 

机构地区：[1]河北医科大学第一医院临床营养科,河北石家庄050031 [2]河北医科大学流行病与统计学教研室,河北石家庄050017

出　　处：《临床荟萃》2014年第9期972-977,共6页Clinical Focus

摘　　要：目的采用meta分析的方法综合评价瘦素受体基因Gln223Arg多态性与高血压发病的相关性。方法通过检索中国学术期刊全文数据库（CNKI）、Google Scholar和Pubmed等,收集1999年1月至2013年6月国内外公开发表的关于瘦素受体基因Gln223Arg多态性与高血压关系的病例对照研究,应用meta分析方法对多个研究进行数据合并与分析。结果共纳入14篇病例对照研究文献,其中高血压患者2 751例,对照组2 425例,中国人（黄种人）2 337例,白种人414例。Meta分析结果显示,显性模型携带GA＋AA基因型的人群发生高血压的风险是GG基因型的1.82倍（OR=1.82,95%CI=1.44～2.30,P=0.000）;按种族进行亚组分析,白种人显性模型携带GA＋AA基因型的人群发生高血压的风险是GG基因型的1.38倍（OR=1.38,95%CI=0.73～2.63,P=0.324）,中国人显性模型携带GA＋AA基因型的人群发生高血压的风险是GG基因型的1.88倍（OR=1.88,95%CI=1.47～2.42,P=0.000）。隐性模型携带AA基因型的人群发生高血压的风险是GA＋GG基因型的1.23倍（OR=1.23,95%CI=1.04～1.45,P=0.015）;按种族进行亚组分析,白种人隐性模型携带AA基因型的人群发生高血压的风险是GA＋GG基因型的0.75倍（OR=0.75,95%CI=0.56～1.01,P=0.058）,中国人隐性模型携带AA基因型的人群发生高血压的风险是GA＋GG基因型的1.54倍（OR=1.54,95%CI=1.26～1.89,P=0.000）。等位基因A可能是高血压发病的危险因素（OR=1.62,95%CI=1.46～1.80,P=0.000）。结论人群中瘦素受体基因Gln223Arg多态性的AA、GA基因型和等位基因A与高血压发病具有相关性,尤其在中国人中存在明显相关。Objective To evaluate whether leptin receptor（LEPR）gene Gln223 Arg polymorphism is correlated with hypertension.Methods Studies on the relationship between LEPR gene Gln223 Arg polymorphism and hypertension published on Chinese National Knowledge Infrastructure（CNKI）,Google Scholar and Pubmed,from January 1999 to June 2013 were analyzed using meta-analysis method.Odd ratio（OR）and 95% confidence interval（CI）were used to estimate the correlations.Results A total of 14case-control studies were identified,including2 751 cases of hypertension（2 337Chinese/Asian and 414Caucasian）and 2 425 cases as controls.Meta-analysis showed that LEPR gene Gln223 Arg polymorphism had significant correlation with hypertension in both dominant model（GA＋AA vs GG：OR =1.82,95%CI=1.44-2.30,P =0.000）and recessive mode（AA vs GA＋GG：OR =1.23,95%CI=1.04-1.45,P=0.015）.Subgroup analysis based on the race of people showed that the relationship between LEPR gene Gln223 Arg polymorphism and hypertension was not significant in dominant model（OR =1.38,95%CI=0.73-2.63,P =0.324）or recessive model（OR =0.75,95%CI =0.56-1.01,P =0.058）in the Caucasian race,while it was significant in Chinese either in dominant model（OR =1.88,95%CI =1.47-2.42,P =0.000）or in recessive model（OR =1.54,95%CI=1.26-1.89,P =0.000）,as well as in allele A/G（OR =1.62,95%CI =1.46-1.80,P =0.000）.Conclusion There is a correlation between LEPR gene Gln223 Arg polymorphism of AA,GA genotype and allele A and hypertension,especially in Chinese population.

关 键 词：高血压 受体 瘦素 多态性 单核苷酸 META分析 

分 类 号：R544.1[医药卫生—心血管疾病]