血清尿酸与脑梗死复发的相关性分析  

Correlation of serum uric acid with recurrent cerebral infarction in elderly patients： analysis of 1033 cases

作　　者：侯婷婷 张金涛[1] 张永红[2] 许锬[2] 周翠玲 赵玉兰[1] 曹发乐 

机构地区：[1]解放军88医院神经内科,泰安271000 [2]苏州大学公共卫生学院,苏州215123

出　　处：《中华老年多器官疾病杂志》2014年第7期512-515,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：国家自然科学基金（30772236）

摘　　要：目的探讨血清尿酸水平与老年脑梗死患者复发的关系。方法以2006年1月1日至2008年12月30Et期间在山东省4家医院住院的老年急性脑梗死患者1033例为研究对象，采用回顾性分析方法，收集人口统计学、生活方式、疾病史、入院尿酸水平以及脑梗死病史。采用多因素分析方法分析尿酸水平与脑梗死复发的关系。结果复发脑梗死患者尿酸水平明显高于初发脑梗死患者，多因素调整后尿酸水平每升高1个单位，脑梗死患者复发的相对危险性比值比（OR）（95％可信区间CI）为1．002（1．000～1．003），显示尿酸水平升高与脑梗死复发相关联。进一步按尿酸四分位数进行分析，与尿酸最低四分位（〈211lμmol／L）水平的脑梗死患者相比，尿酸水平在263～333μmol／L、≥333μmol／L的患者发生不良结局的OR值（95％CI）分别为1．951（1．340～2．839）、1．670（1．140～2．448）。而在211~263μmol／L水平，这种趋势无统计学意义。结论血清尿酸水平升高是脑梗死复发的独立危险因素。Objective To investigate the correlation between the level of serum uric acid （SUA） and recurrent cerebral infarction in elderly patients. Methods A total of 1033 acute ischemic stroke patients from 4 hospitals in Shangdong Province from January 2006 to December 2008 were recruited in the study. Data on demographic characteristics, life style, history of disease, SUA at admission and history of cerebral infarction were collected for all participants. Multi-variate non-conditioned logistic regression analysis was used to analyze the correlation of SUA and recurrent cerebral infarction. Results The SUA level was significantly higher in the patients with recurrence of cerebral infarction than in those with primary cerebral infarction. After adjustment for multivariate, the odds ratio （OD） [95% confidence interval （CI）] of recurrence was 1.002 （1.000-1.003） for every increased unit, indicating the association of SUA and recurrent cerebral infarction. Logistic analysis was then conducted according to quartile of SUA level. The results showed that the OD （95% CI） of recurrence was 1.951 （1.340-2.839） and 1.670 （1.140-2.448）, respectively for the patients with SUA of 263 to 333μmol/L and t〉 333μmol/L, when compared to those with SUA 〈 211μmol/L. But there was no significant difference in those with SUA of 211 to 263μmol/L. Conclusion Elevated SUA is an independent predictor for the recurrence of cerebral infarction.

关 键 词：脑梗死 卒中 尿酸 复发 老年人 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学] R743.3[医药卫生—基础医学]