急性冠脉综合征患者血浆MCP-1、F1+2水平及其与心功能关系  

Relationship of plasma MCP-1 and F1+2 and cardiac function in patients with acute coronary syndrome

作　　者：刘怡[1] 邓军[2] 朱永锋[2] 宗毓[3] 王瑞利[4] 张娟[4] 

机构地区：[1]徐州市中心医院心脏病科,江苏省221000 [2]徐州医学院附属第三医院心脏病科 [3]徐州医学院心血管病研究所 [4]江苏省睢宁县人民医院心脏病科

出　　处：《江苏医药》2014年第15期1791-1793,共3页Jiangsu Medical Journal

基　　金：徐州市科技发展基金项目(XF11C101)

摘　　要：目的探讨急性冠脉综合征(ACS)患者血浆单核细胞趋化蛋白1(MCP-1)和凝血酶原片段1+2(F1+2)水平及其与心功能的关系。方法 ACS患者61例分为急性心肌梗死组(AMI组,33例)和不稳定型心绞痛组(UAP组,28例),以稳定型心绞痛15例(SAP组)和健康体检者15名(C组)作为对照。ELISA法测定各组患者胸痛发作后6h时血浆MCP-1和F1+2水平。ACS患者根据纽约心脏病协会心功能分级标准分为四个亚组,并行超声心动图检测和组间比较。结果 AMI组和UAP组血浆MCP-1和F1+2水平均高于SAP组,AMI组血浆MCP-1和F1+2水平高于UAP组,SAP组血浆MCP-1高于C组(P<0.05)。随着心功能级数增加,ACS四个亚组血浆MCP-1和F1+2水平升高,而左室射血分数(LVEF)水平下降(P<0.05)。血浆MCP-1和F1+2水平与心功能分级呈正相关(r=0.692,r=0.655,P<0.01),与LVEF水平呈负相关(r=-0.674,r=-0.617,P<0.05),且MCP-1与F1+2有较好的相关性(r=0.658,P<0.05)。结论联合检测血浆MCP-1和F1+2水平有助于ACS的早期诊断和预后判断。Objective To explore the relationship of plasma monocyte chemotactic protein 1 （MCP-1） and prothrombin fragment 1 ＋ 2 （F1 ＋ 2） and cardiac function in patients with acute coronary syndrome（ACS）. Methods Sixty-one patients with ACS were divided into groups of AMI （acute myocardial infarction, 33 cases） and UAP（unstable angina pectoris, 28 cases）. Fifteen patients with stable angina pectoris（group SAP） and 15 healthy people（group C） were selected as the controls. Plasma MCP-1 and Fl＋2 were detected by ELISA at 6 hours after chest pain. On the basis of cardiac function standard of New York Heart Association, four subgroups of ACS patients received ultrasonic cardiography. Results Plasma levels of MCP-1 and F1 ＋ 2 were higher in groups of AMI and UAP than those in group SAP, which were higher in group AMI than those in group UAP （P〈0.05）. Plasma MCP-1 in group SAP was higher than that in group C（P〈0.05）. With an increase of cardiac function grading, plasma levels of MCP-1 and F1 ＋ 2 elevated, while left ventricular ejection fraction（LVEF） declined（P〈0. 05）. Plasma levels of MCP-1 and F1 ＋ 2 were positively correlated with cardiac function grade（r=0. 692, r= 0. 655, P〈0. 01）, but negatively correlated with LVEF（r= - 0. 674, r= - 0. 617, P〈0. 05）. Conclusion Combined detection of plasma MCP- 1 and F1 ＋2 is helpful in the early diagnosis and evaluation of the prognosis in the patients with ACS.

关 键 词：急性冠脉综合征 单核细胞趋化蛋白1 凝血酶原片段1+2 

分 类 号：R541[医药卫生—心血管疾病]