阻塞性睡眠呼吸暂停低通气综合征患者早期认知功能损害的事件相关电位研究  

Early Signs of Cognitive Impairment in Patients with Obstructive Sleep Apnea Hypopnea Syndrome:An Event-Related Potential Study

作　　者：邹可[1] 孙元锋[1] 唐向东[1] 雷飞[1] 杜丽娜[1] 陈喆思[2] 鄢婷婷[3] 郑重[1] 

机构地区：[1]四川大学华西医院睡眠医学中心,成都610041 [2]成都中医药大学针灸推拿学院,成都610072 [3]四川大学-香港理工大学灾后重建与管理学院,成都610065

出　　处：《生物医学工程学杂志》2014年第4期870-874,共5页Journal of Biomedical Engineering

基　　金：国家自然科学青年基金资助项目(81300065)

摘　　要：探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者早期认知功能损害情况。根据多导睡眠监测(PSG)结果,对符合OSAHS诊断的20例患者和20例正常对照进行事件相关电位失匹配负波(MMN)和P300检测。结果显示OSAHS组Cz点的MMN和P300潜伏期较对照组显著延长(P<0.05)。在控制了年龄和体重的影响后,相关分析显示MMN潜伏期与呼吸暂停低通气指数(AHI)、氧减指数、N1期睡眠时间和微觉醒指数呈显著正相关(P<0.01),与N3期睡眠时间和平均血氧饱和度呈显著负相关(P<0.05);P300潜伏期与AHI和氧减指数呈显著正相关(P<0.05);没有发现MMN潜伏期、波幅与P300潜伏期、波幅具有相关关系。OSAHS患者大脑自动加工和控制加工功能受损,与夜间反复低氧和睡眠结构紊乱有关。This study seeks to explore the early signs of cognitive impairment in patients with obstructive sleep apnea hypopnea syndrome （OSAHS）. According to polysomnography, twenty patients diagnosed with OSAHS and twenty normal controls underwent event-related potential （ERP） examination including mismatch negativity （MMN） and P300. Compared with normal controls, OSAHS patients showed significantly prolonged latency of MMN and P300 at Cz. After controlling age and body mass index （BMI）, MMN latency positively correlated with apnea hypopnea index （AHI）, oxygen reduction index, stage N1 sleep and arousal index, while MMN latency negatively correlated with stage N3 sleep and mean blood oxygen saturation; and Pa00 latency positively related to AHI and oxygen reduction index; no relationships were found among MMN latency, MMN amplitude, P300 latency and P300 amplitude. These results suggest that the brain function of automatic processing and controlled processing acre impaired in OSAHS patients, and these dysfunction are correlated with nocturnal repeatedly hypoxemia and sleep structure disturbance.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 认知功能损害 事件相关电位 

分 类 号：R766[医药卫生—耳鼻咽喉科]