利奈唑胺在肝功能受损患者中的应用  

Use of linezolid in hepatic impairment patients

作　　者：曹伟[1] 卢志品[1] 余剑华[2] 

机构地区：[1]厦门大学附属第一医院药学部,福建厦门361003 [2]厦门大学附属第一医院重症医学科,福建厦门361003

出　　处：《中国新药与临床杂志》2014年第8期559-562,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：利奈唑胺为新型噁唑烷酮类抗菌药物,可用于耐药革兰阳性菌感染。因其由非肝药酶途径代谢,利奈唑胺说明书提示轻、中度肝功能不全者无须调整剂量,重度肝功能不全者尚未有相关研究。本文分析、总结了利奈唑胺在肝功能受损患者中的应用情况。Linezolid is an oxazolidninone, which is indicated to the infection of resistant Gram-positive bacteria. Due to its nonrenal and nonenzymatic clearance pathways, the label of linezolid suggests that no dose adjustment is recommended to patients with mild-to-moderate hepatic impairment and its use in severe hepatic impairment has not been evaluated. This paper analyzed and summarized the use of linezolid in hepatic impairment patients.

关 键 词：利奈唑胺 肝功能不全 血小板减少 

分 类 号：R978.1[医药卫生—药品]