OSAHS患者正压通气治疗后促红细胞生成素及血液流变学的变化  

Changes of Erythropoietin and Hemorheology in OSAHS Patients under Positive Pressure Ventilation Intervention

作　　者：董凯峰[1] 薛静[1] 刘志明[1] 吕欣[1] 张继华[1] 薛海涛[1] 孔祥玲[1] 韩彩丽[1] 

机构地区：[1]河北医科大学第一医院耳鼻咽喉头颈外科,050031

出　　处：《天津医药》2014年第8期786-789,共4页Tianjin Medical Journal

基　　金：河北省科学技术研究与发展计划项目(112761137)

摘　　要：目的观察中重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者经无创正压通气(NPPV)治疗后血清促红细胞生成素(EPO)及血液流变学水平变化。方法选择40例诊断为中重度OSAHS患者(OSAHS组)和40例健康查体者(对照组),OSAHS组行NPPV治疗3个月,分别检测治疗前及治疗后1、3个月时血清EPO血常规、血液流变学指标,监测睡眠呼吸暂停低通气指数(AHI)、夜间平均最低血氧饱和度(LSaO2),对照组于相同时间点也进行上述指标检测。结果 OSAHS组与对照组各时间点血清EPO、血常规、血液流变学各指标、AHI、LSaO2经重复测量设计的方差分析组间、时间之间及组间与时间交互作用均有统计学意义;OSAHS组各指标均随治疗时间延长逐渐改善,对照组各指标均在正常范围。结论 OSAHS患者经NPPV治疗可以明显改善缺氧程度,降低血清EPO水平及血液黏度对于防治OSAHS及其并发症有重要临床意义。Objective To observe changes of erythropoietin （EPO） and rheology in moderate and severe obstructive sleep apnea hypopnea syndrome （OSAHS） patients after the noninvasive positive pressure ventilation （NPPV） treatment. Methods Healthy adults were selected as control group （n=40） while moderate to severe OSAHS patients were selected as OSAHS group. OSAHS group was underwent NPPV treatment then, Levels of sleep apnea hypopnea index （AHI）, sleep mean minimum oxygen saturation （LSaO2） and serum erythropoietin （EPO） were assessed, routine blood test and hemodynam-ic indexes were also checked before treatment and 1 and 3 months after treatment in both groups. Results In both groups serum EPO, blood, blood rheology indexes, AHI, LSaO2 were analysised at each time point by ANOVA repeated measures, all of which show significant different between groups and between each time points within the same group. Indexes in OSAHS group improved with prolonged treatment , but they are in the normal range in the control. Conclusion OSAHS pa-tients with NPPV therapy can significantly relieve hypoxia, reduce serum EPO level and blood viscosity. So NPPV has impor-tant clinical significance in prevention and treatment of OSAHS.

关 键 词：正压呼吸 睡眠呼吸暂停综合征 红细胞生成素 血液流变学 血氧饱和度 

分 类 号：R76[医药卫生—耳鼻咽喉科]