正常范围甲状腺激素水平与冠状动脉Gensini评分的相关性分析  

Relationship between Normal Thyroid Hormone Levels with Gensini Coronary Scoring System

作　　者：肖健勇[1] 曹路[1] 丛洪良[1] 

机构地区：[1]天津市胸科医院心内科,天津市心血管病研究所,300222

出　　处：《天津医药》2014年第8期793-795,804,共4页Tianjin Medical Journal

基　　金：天津市科技计划项目(12ZCZDSY03200)

摘　　要：目的探讨甲状腺功能正常的冠心病患者甲状腺激素水平与冠状动脉Gensini评分的关系。方法选取231例均行冠状动脉造影且确诊为冠心病患者,同时测定总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)和促甲状腺激素(TSH),其值均在正常范围,同时通过造影结果计算Gensini积分,依据Gensini积分分为4组并进行积分与各种检验指标的相关分析。结果 4组不同病变程度的冠心病患者TT3、TT4、FT4、TSH、CHO、TG的差异均无统计学意义(P>0.05),FT3、HDL-C随着冠脉病变程度的增加而降低(P<0.01),年龄、LDL-C随着冠脉病变程度的增加而增加,且有统计学意义(P<0.05)。Gensini积分与FT3、HDL-C呈直线负相关,与年龄、LDL-C呈正相关。年龄、FT3、HDL-C、LDL-C与Gensini积分呈独立相关。结论在甲状腺功能正常时,FT3可作为冠心病患者病变程度的独立危险因素。Objective To study the correlation between normal level of thyroid hormone and gensini coronary scor-ing system. Methods Coronary heart disease patient who were treated with Cardio-angiography （CAG） （n=231） were divid-ed into 4 groups based on gensini coronary score. All the patients were examined with indexes include total triiodothyronine （TT3）, total thyronine（TT4）, free thyronine（FT4）, free triiodothyronine （FT3）, thyroid stimulating hormone （TSH）. And correla-tion between thyroid hormone level and gensini coronary scoring system was studied by Spearman correlation analysis and Multiple regression analysis. Results No significant difference was found in the levels of TT3, TT4, FT4, Cholesterol（CHO） and Triglyceride（TG） between the all 4 groups （P〉0.05）. FT3 and HDL-C decreased with the increase of extent of coronary artery lesions（P〈0.01）, and AGE and LDL-C raised with the coronary artery lesions extent （P〈0.05）. Gensini coronary scoring system was linearly negatively correlated with FT3, HDL-C and positively correlated with age and LDL-C. Age, FT3,HDL-C,LDL-C was independently correlated to Gensini score. Conclusion The lower level of FT3 is an indepen-dent risk factor for CHD.

关 键 词：甲状腺素 三碘甲状腺原氨酸 冠心病 GENSINI评分 

分 类 号：R541.4[医药卫生—心血管疾病]