氟哌啶醇在肝移植术后精神障碍中的应用  

Treatment of haloperidol in psychiatric disorders after liver transplantation

作　　者：魏思东[1] 陈国勇[1] 孙建军[1] 汤高枫[1] 谢占涛[1] 周绍棠[1] 

机构地区：[1]郑州人民医院肝胆胰腺外科,河南郑州450003

出　　处：《外科理论与实践》2014年第4期314-316,共3页Journal of Surgery Concepts & Practice

基　　金：国家自然科学基金资助项目(81370577);郑州市博士创业基金(2013-62);郑州市科技局项目(N2013SC0717)

摘　　要：目的:观察氟哌啶醇在肝移植术后精神障碍中的疗效。方法:回顾性分析我院2012年7月至2013年12月肝移植术后发生精神障碍受者使用氟哌啶醇的疗效与不良反应。结果:本研究受者发生精神障碍31例,占所有87例肝移植受者的35.6%,共使用氟哌啶醇72次,22例明显改善,5例好转,3例效果差,1例出现锥体外系反应,改用地西泮治疗。结论:精神障碍为肝移植术后常见的并发症,氟哌啶醇治疗具有较好的效果,大剂量使用时注意其不良反应。Objective To observe the effect of haloperidol in treatment of psychiatric disorders after liver transplantation. Methods Retrospective analysis was done in liver transplanted patients with psychiatric disorders in our hospital from July 2012 to December 2013 for efficacy and adverse reaction of haloperidol. Results The psychiatric disorders were found in 31 of 87 （35.6%） liver transplanted patients. The treatment of haloperidol was efficient in 22 cases, good in 5 cases and poor in 3 cases. There were 72 times of use of haloperidol in all 31 patients. Haloperido had to be changed to diazepam in one case for extrapyramidal reactions. Conclusions Psychiatric disorders are common complications of liver transplanted patients. Haloperidol is efficient agent and side effect should be considered when large dose is used.

关 键 词：氟哌啶醇 肝移植 精神障碍 治疗 

分 类 号：R657.3[医药卫生—外科学]