经皮穴位电刺激对围术期肺癌患者免疫功能的调节  

The regulation of transcutaneous electrical acupoint stimulation on immune function in perioperative patients with lung cancer

作　　者：吴华星[1,2] 孟德新[1] 王坤[3] 全丽娜[4] 孔庆玲[3] 张国莉[5] 韩嘉晟[1] 李瑰贤[2] 李钰[6] 王国年[3,6] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院内镜室,哈尔滨150081 [2]哈尔滨工业大学机电学院 [3]哈尔滨医科大学附属肿瘤医院麻醉科 [4]哈尔滨医科大学附属肿瘤医院血液淋巴内科 [5]哈尔滨医科大学附属肿瘤医院胸外科 [6]哈尔滨工业大学生命科学与技术学院

出　　处：《中国康复医学杂志》2014年第8期731-735,共5页Chinese Journal of Rehabilitation Medicine

基　　金：黑龙江省科技厅重大攻关课题(GB05C402-14);哈尔滨市科技创新人才(2013RFXYJ031)

摘　　要：目的:探讨经皮穴位电刺激(TEAS)对单侧肺叶切除的围术期肺癌患者T淋巴细胞、NK细胞及相关细胞因子的影响。方法:选择择期行肺癌根治术的患者40例,随机分为手术组和TEAS手术组。TEAS手术组从麻醉诱导前30min至术毕持续TEAS,术后连续3天行间断TEAS,手术组与TEAS手术组均于术前30min、术毕、术后1、3、5天检测外周血中CD3+、CD4+、CD8+、NK细胞的水平,CD4+/CD8+比值以及sIL-2R、IL-2、IFN-γ、IL-10的浓度。结果:与手术组相比,TEAS手术组术后1、3、5天CD3+、CD4+、CD4+/CD8+比值、NK细胞水平升高明显,术后3、5天CD8+、sIL-2R、IL-10的表达均明显降低,而IL-2、IFN-γ的表达均明显升高(P<0.05)。结论:经皮穴位电刺激可以增强围术期肺癌患者的免疫功能,减轻免疫抑制,并且能明显增强术后患者的镇痛效果,减少术后镇痛药的用量。Objective： To investigate the effect of transcutaneous electrical acupoint stimulation（TEAS） on T lymphocyte subgroup, natural killer cell（NK cells） and its related cytokines secretion in perioperative lung cancer patients undergoing lobectomy. Method： Forty patients with pulmonary carcinoma were randomly divided into surgical group and TEAS surgical group. The patients in TEAS surgical group received TEAS stimulation for 30min from 30min before operation to l, 2 and 3 days after operation. The levels of blood CD3＋, CD4＋, CD8＋ and CD4＋/CD8＋ ratio as well as NK cells, and the concentrations of sIL-2R, IL-2, IFN-y and IL-10 were determined at 30min before opera- tion, at the end of operation and at 1, 3 and 5 d after operation. Result： The levels of CD3＋, CD4＋, CD47CD8＋ ratio and NK cells in TEAS surgical group increased significantly at postoperative 1, 3 and 5 days compared with in surgical group. The expressions of CD8＋, sIL-2R and IL- 10 decreased significantly at postoperative 3 and 5 days, while the expressions of IL-2 and IFN-y increased significantly（P 〈0.05）. Conclusion： TEAS may enhance the immune function of perioperative patients with lung cancer, strengthen the postoperative analgesia effect and reduce the analgesic consumption of postoperation. Author＇s address Harbin Medical University Cancer Hospital, 150081.

关 键 词：肺癌 经皮穴位电刺激 T淋巴细胞亚群 细胞因子 

分 类 号：R246.5[医药卫生—针灸推拿学]