PET/CT诊断非小细胞肺癌纵隔淋巴结分期的准确性研究——Meta分析  

Accuracy of Mediastinal Lymph Node Staging in Non-small Cell Lung Cancer by PET/CT——Meta-analysis

作　　者：李晓翠[1] 苗丽琼[1] 钱靖[1] 吴云坤[1] 杨青[1] 

机构地区：[1]云南省玉溪市人民医院病案管理科,云南玉溪653100

出　　处：《中国医学影像学杂志》2014年第7期540-546,共7页Chinese Journal of Medical Imaging

摘　　要：目的 通过Meta分析评估PET/CT诊断非小细胞肺癌纵隔淋巴结分期的准确性.资料与方法 通过Cochrane Library、PubMed、中国生物医学光盘数据库（CBMdisc）、中国期刊全文数据库（CNKI）、万方和维普等数据库收集2000～2011年已发表的有关PET/CT诊断非小细胞肺癌纵隔淋巴结分期的文献,按预设标准对文献进行筛选和质量评价.使用Meta-Disc软件进行Meta分析,绘制汇总受试者工作特征曲线,计算曲线下面积（AUC）和Q＊指数.结果 符合纳入标准的文献共27篇（3667例患者）.以患者为研究对象,诊断的灵敏度和特异度分别为0.78 （95％ CI0.76～0.81）、0.87 （95％ CI 0.85～0.88）,AUC和Q＊指数分别为0.8869、0.8175.以淋巴结为研究对象,诊断的灵敏度和特异度分别为0.66（95％CI0.64～0.69）、0.94（95％CI 0.94～0.95）,AUC和Q＊指数分别为0.9197、0.8530.结论 PET/CT诊断非小细胞肺癌纵隔淋巴结分期的准确度高,具有较大的临床应用价值,但其灵敏度有待进一步提高.Purpose To assess the accuracy of mediastinal lymph node staging in non-small cell lung cancer using PET/CT by Meta-analysis.Materials and Methods Literatures on mediastinal lymph nodes staging of non-small cell lung cancer literature by PET/CT published from 2000 to 2011 were filtered and quality-assessed according to preset criteria from the Cochrane Library,PubMed,Chinese Biomedical CD library （CBMdisc）,CNKI,Wanfang database,VIP and other database.Meta-analysis was performed using Meta-Disc software,and receiver operating characteristic curve was applied,area under the curve （AUC） and Q＊ index were calculated.Results 27 relevant literatures were in accordance with the inclusion criteria （3667 patients）.The diagnostic sensitivity and specificity based on the patients were 0.78 （95％ CI 0.76-0.81） and 0.87 （95％ CI 0.85-0.88）,AUC and Q＊ index were 0.8869 and 0.8175.The diagnostic sensitivity and specificity based on lymph nodes were 0.66 （95％ CI 0.64-0.69） and 0.94 （95％ CI 0.94-0.95）,AUC and Q＊ index were 0.9197 and 0.8530.Conclusion PET/CT has a high accuracy for the mediastinal lymph node staging in non-small cell lung cancer with high clinical applicable value,but its sensitivity needs to be improved.

关 键 词：癌 非小细胞肺 肿瘤转移 纵隔 淋巴结 肿瘤分期 正电子发射断层显像术 体层摄影术 X线计算机 META分析 

分 类 号：R734.2[医药卫生—肿瘤] R730.42[医药卫生—临床医学]