替米沙坦对不稳定型心绞痛患者内皮祖细胞数量及高敏C-反应蛋白的影响  

Effects of telmisartan on endothelial progenitor cells and high sensitive C-reactive protein in patients with unstable angina pectoris

作　　者：倪卫[1] 

机构地区：[1]内江市第一人民医院心内科,四川省内江市641000

出　　处：《中国组织工程研究》2014年第29期4701-4705,共5页Chinese Journal of Tissue Engineering Research

基　　金：四川省科技厅自然科学基金计划(05JY029-105-1)~~

摘　　要：背景:动脉粥样硬化斑块是人体内低程度的慢性炎症反应。替米沙坦具有降血压、保护靶器官和抑制炎症的作用,还可部分激动过氧化物酶增殖物活化受体γ受体,增加内皮祖细胞数量,抑制粥样斑块血管壁细胞的炎症反应。目的:观察替米沙坦对不稳定型心绞痛患者外周血内皮祖细胞及高敏C-反应蛋白的影响。方法:选择2012年1月至2013年12月期间于内江市第一人民医院就诊的不稳定型心绞痛患者200例,随机分为常规治疗组和替米沙坦治疗组,每组100例。统计每位患者的一般临床资料,测定治疗前、治疗4,8周后患者外周血中内皮祖细胞的数量和高敏C-反应蛋白水平。结果与结论:治疗4,8周后,替米沙坦治疗组的内皮祖细胞数量百分比均较治疗前和常规治疗组有明显升高(P<0.05)。外周血高敏C-反应蛋白水平分析表明,治疗4,8周后,两组高敏C-反应蛋白水平均降低,且替米沙坦治疗组明显低于常规治疗组(P<0.05)。结果证实,替米沙坦具有动员内皮祖细胞,促进血管内皮修复,降低高敏C-反应蛋白水平,抑制炎症反应的作用。BACKGROUND： Atherosclerotic plaque is chronic low-level inflammation in human body. Telmisartan can lower blood pressure, protect the target organs and inhibit inflammation, also partially activate peroxisome proliferator-activated receptor y, increase the number of progenitor cells, and inhibit inflammation of vascular wall cells. OBJECTIVE： To observe the effects of telmisartan on endothelial progenitor cells and high-sensitivity C-reactive protein in peripheral blood of patients with unstable angina pectoris. METHODS： 200 patients with unstable angina pectoris who consulted the doctors of the First People＇s Hospital of Neijiang from January 2012 to December 2013 were randomly divided into contrast group and telmisartan group, with 100 patients in each group. The general clinical data of each patient was collected. Peripheral venous blood was taken before treatment and 4, 8 weeks after treatment. Endothelial progenitor cells and high-sensitivity C-reactive protein level were detected. RESULTS AND CONCLUSION： At 4 and 8 weeks after treatment, the percentage of endothelial progenitor cells in telmisartan group was significantly higher than those before treatment and that of contrast group （P 〈 0.05）. At 4 and 8 weeks after treatment, the high-sensitivity C-reactive protein level was decreased significantly in telmisartan group compared with before treatment. The telmisartan group had a significantly lower level than the contrast group （P 〈 0.05）. Telmisartan can promote the proliferation of endothelial progenitor cells and restoration of damaged vessels. It can also reduce high-sensitivity C-reactive protein level and inhibit the inflammatory reaction.

关 键 词：不稳定型心绞痛 替米沙坦 内皮祖细胞 高敏C-反应蛋白 治疗 组织构建 血管内皮细胞 冠状动脉粥样硬化型心脏病 炎症反应 过氧化物酶增殖物活化受体γ 

分 类 号：R318[医药卫生—生物医学工程]