超声波对高分子材料降解过程启动的控制  

Ultrasonic controlling of degradation of polymer materials

作　　者：高喜翔[1] 张建[1] 陈兵[1] 谷涌泉[1] 李建新[1] 张淑文[1] 叶霖[2] 冯增国[2] 

机构地区：[1]首都医科大学宣武医院血管外科,北京市100053 [2]北京理工大学材料科学与工程学院,北京市100081

出　　处：《中国组织工程研究》2014年第30期4868-4872,共5页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金资助项目(30972944);北京市科学技术委员会"首都临床特色应用研究"专项资助课题(Z131107002213041)~~

摘　　要：背景:可降解高分子材料在植入体内后其降解过程就开始启动,如何能控制可降解材料降解过程的启动,做到定时、定位启动,国内外鲜有研究。目的:研究超声波对高分子材料降解过程启动的控制。方法:将ε-己内酯/L-丙交酯共聚物制成样本的可降解内核,在其表面通过4种方法涂覆低密度聚乙烯疏水涂层:1先将内核表面黏附一薄层CaCl2粉末,而后将聚乙烯涂覆于其表面。2先将聚乙烯涂覆于内核表面,静置粗化3 h。3将内核表面黏附一薄层CaCl2粉末,而后将聚乙烯涂覆于其表面,静置粗化3 h。4直接将聚乙烯涂覆于内核表面。将4种样本包埋于带皮猪肉内进行体外超声波轰击实验。结果与结论:方法1、4制备的样本,在轰击前其疏水层能够保护内核材料,其浸泡液在631 nm处无吸收峰值;轰击后由于疏水层破损,甲苯胺蓝染料被释放出来,造成溶液颜色改变及631 nm处吸收峰值明显升高。方法2、3制备的样本,在轰击前其疏水层未能起到保护作用,其浸泡液在631 nm处出现吸收峰值。电镜扫描显示4组样本在超声波作用下发生了明显表面容貌变化。表明采用低密度聚乙烯制作的疏水层可以保护内核ε-己内酯/L-丙交酯共聚物材料,以体外超声波作为诱发因素,可以控制可降解内核降解过程的启动。BACKGROUND： Degradable polymer materials initiate the degradation process immediately after implantation. How to regulate the degradation of these materials is rarely reported at present. OBJECTIVE： To study the effect of ultrasonic wave on controlling the degradation of polymer materials. METHODS： The sample is made of ε-caprelactone/L-lactide copolymer, and its core was coated with low density polyethylene on the surface with the following four different methods. （1） The core surface was firstly covered with CaCI2 powder, and then coated with polyethylene. （2） The core was firstly coated with polyethylene and coarsened for 3 hours. （3） The core surface was firstly covered with CaCI2 powder, and then coated with polyethylene, and coarsened for 3 hours. （4） The core was directly coated with polyethylene. The four kinds of specimens obtained were embedded in pork for ultrasonic bombardment experiment in vitro. RESULTS AND CONCLUSION： In the specimens prepared with methods 1 and 4, the lyophobic layer could protect core materials before ultrasonic treatment, and no absorption peak was found at 631 nm. After ultrasonic treatment, the lyophobic layer was destroyed, toluidine blue dye was released, leading to change the color of immersion solution and increase the absorption peak at 631 rim. In the specimens prepared with methods 2 and 3the lyophobic layer cannot exhibit the protection effects, the absorption peak was found at 631 nm. Under electron microscope, the appearance of the specimens in four groups was changed obviously. It is feasible to control the starting of the degradation by coating the degradable copolymer with LDPE and using ultrasonic as a trigger.

关 键 词：生物材料 共聚物 Ε-己内酯 L-丙交酯 生物可降解材料 低密度聚乙烯 组织工程人工血管 药物控释 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]