儿童肺炎支原体肺炎临床特点及血浆分泌型白细胞蛋白酶抑制剂的水平变化  

Analysis on clinical features and plasma SLPI levels in children with Mycoplasma pneumoniae pneumonia

作　　者：沈夏梦 华春珍[1,2,3] 王晓芳[2] 庞福珍 

机构地区：[1]杭州师范大学医学院,浙江杭州310002 [2]杭州师范大学附属医院,浙江杭州310000 [3]浙江大学医学院附属儿童医院,浙江杭州310000 [4]天台县人民医院,浙江天台317200

出　　处：《临床儿科杂志》2014年第8期720-723,共4页Journal of Clinical Pediatrics

基　　金：浙江省医药卫生科技计划项目(No.2011KYA128);杭州市医药卫生科技计划项目(No.2011A020)

摘　　要：目的分析肺炎支原体肺炎(MPP)患儿的临床特点及其血浆分泌型白细胞蛋白酶抑制剂(SLPI)水平的变化。方法比较分析136例MPP住院患儿的临床资料及血浆SLPI水平。结果 136例MPP患儿中男80例、女56例,>4岁占82.4%。有发热者92.7%,反复剧烈咳嗽83.8%,肺部曾闻及干湿啰音74.3%。所有患儿胸片均可见大片状或斑片状阴影。急性期白细胞计数降低72.1%,中性粒细胞百分数正常59.6%,超敏C反应蛋白(hs-CRP)增高63.2%。85例查急性期血浆SLPI水平为(9.3±8.8)ng/ml,恢复期为(11.8±8.0)ng/ml,差异有统计学意义(Z=3.08,P=0.002)。结论 MPP临床特点以发热、反复剧烈咳嗽、胸片见大片状或斑片状阴影为主,外周血白细胞计数不增高,中性粒细胞比例正常而hsCRP增高。MPP患儿急性期血浆SLPI水平明显低于恢复期。Objective To analyze the clinical features and the plasma secretory leukocyte proteinase inhibitor （SLPI） levels in children with Mycoplasma pneumoniae pneumonia （MPP）. Methods Clinical data and plasma SLPI levels of 136 children with MPP were retrospectively analyzed. Results From July 2011 to June 2013,136 children （male 80, female 56） with MPP were included in the study. The onset ages of all children ranged from 11 months to 14 years （mean age, 6.2±3.0 years）, and 82.4% of the cases were at the age of 4 to 14 years. One hundred and twenty six cases （92.7%） with long-last high fever, 83.8% with cough, 74.3% with rale were found in the study. Small or large patchy shadows in chest X-ray radiography were found in all the cases. At the acute phase, 72.1% with low white blood cell count, 59.6% with normal neutrophil cell and 63.2% with higher high sensitive C-reactive protein （hs-CRP） were observed. The SLPI level at the acute phase in 85 cases was （9.3±8.8） ng/ml, which was significant lower than that at the convalescent phase （11.8±8.0 ng/ml, Z = 3.08, P = 0.002）. Conclusions The clinical features of MPP are usually presented with high fever, cough, higher hs-CRP, normal or lower white blood cell and neutrophil cell count, small or large patchy shadows in chest X-ray radiography. The plasma SLPI level at the acute phase was significantly lower than that in convalescent phase in children with MPP.

关 键 词：肺炎支原体 肺炎 分泌型白细胞蛋白酶抑制剂 儿童 

分 类 号：R725.6[医药卫生—儿科]