急性脑梗死患者血栓前状态特征分析402例  

Characterisitics analyze of the prethrombotic state of 402 acute cerebral infarction

作　　者：潘慧芳[1] 高庆双[1] 赵玉萍[1] 

机构地区：[1]唐山市妇幼保健院检验科,河北唐山06300

出　　处：《世界最新医学信息文摘》2014年第15期38-39,共2页World Latest Medicine Information Electronic Version

摘　　要：目的探讨急性脑梗死患者血栓前状态（PTS）血浆纤维蛋白原（FIB）含量和血液流变学指标的变化。方法用全自动血凝仪和全自动血液流变分析仪分别检测402例急性脑梗死患者发病24小时内及384例健康对照组血浆纤维蛋白原（Fro）含量和全血粘度（高切200s／mpa．s低切5s／mpa．s）血浆粘度、红细胞聚集指数。结果急性脑梗死患者血浆纤维蛋白原（FIB）含量和全血粘度（高切200s／mpa．S低切5s／mpa．s）血浆粘度、红细胞聚集指数明显增高，与健康对照组比较有非常显著差异（P〈0．05）。结论血浆纤维蛋白原（FIB）含量和血液流变学指标的测定可以作为脑梗死患者血栓前状态初筛实验。Objective To explore characteristics of prethrombotic state of acute cerebral infarction（ACI） by measuring levels of plasma fibrinogen and theological indices. Methods Plasma fibrinogen, whole blood viscosity （high and low shear）, plasma viscosity, and erythrocyte aggregation index were measured by using full automatic blood coagulation analyzer and full automatic blood viscosity analyzer in 402 ACI within 24 hours of onset subjects and in 384 healthy control subjects. Results Plasma fibrinogen, whole blood viscosity （high shear 200 s/mpa.s and low shear 5s/mpa.s ）, plasma viscosity, and erythrocyte aggregation index in ACI subjects markedly increased as compared with the healthy control subjects with statistically significant difference （P 〈0.05）. Conclusion Determination of levels of plasma fibrinogen and blood rheological indices may be utilized as screening test for the prethombotic state of ACI.

关 键 词：脑梗死 血栓前状态 纤维蛋白原 血液流变学 

分 类 号：R543[医药卫生—心血管疾病]