基于可变翻转角技术快速测量组织T1值的可行性  

Feasibility of rapid imaging protocol based on variable flip angles technique for T1measurement

作　　者：叶枫[1] 欧阳汉[1] 宋颖[1] 余小多[1] 

机构地区：[1]北京协和医学院中国医学科学院肿瘤医院影像诊断科,北京100021

出　　处：《中国医学影像技术》2014年第8期1247-1250,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨可变翻转角结合三维(3D)容积内插快速扰相梯度回波(FSPGR)序列快速测量T1值的可行性。方法采用不同浓度钆溶液作为模型,以单层反转恢复快速自旋回波(IR-FSE)序列为金标准,比较3DFSPGR可变翻转角组合(2、3个翻转角)和3D容积内插FSPGR可变翻转角组合(2、3、4个翻转角)测量模型T1值的准确性。结果 2、3个可变翻转角FSPGR与IR-FSE测量T1值高度相关(r=0.982和0.975,P均<0.001);2、3、4个可变翻转角3D容积内插FSPGR与IR-FSE测量T1值亦高度相关(r=0.969、0.970和0.979,P均<0.001),于不同时间所测得T1值的组内相关系数等于或接近1。结论可变翻转角结合3D容积内插FSPGR可快速测量组织T1值,准确性及重复性较好。Objective To investigate the feasibility of a rapid imaging protocol based on three-dimensional（3D）volumetric interpolated fast spoiled gradient-recalled echo（FSPGR）sequence with variable flip angles（VFAs）for T1 measurement.Methods MR phantoms was established using dilated gadolinium solution with different concentrations and were scanned.The accuracy of 3DFSPGR combined with VFAs and 3Dvolumetric interpolated FSPGR combined with VFAs in measurement of T1 values was assessed with single slice inversion-recovery prepared fast spin echo（IR-FSE）sequence as gold standard.Results T1 values measured by 3DFSPGR combined with 2,3VFAs were highly correlated with T1 values measured by IR-FSE（r=0.982,0.975,both P〈0.001）.T1 values measured by 3Dvolumetric interpolated FSPGR combined with VFAs were also correlated with T1 values measured by IR-FSE（r=0.969,0.970,0.979,respectively,all P〈0.001）.The intraclass correlation coefficient between twice measurement was 1or approximately 1.Conclusion 3D volumetric interpolated FSPGR with VFAs can be applied for fast T1 measurement with good accuracy and repeatability.

关 键 词：磁共振成像 可变翻转角 扰相梯度回波序列 体模 显像术 

分 类 号：R445.2[医药卫生—影像医学与核医学]