补肾通督胶囊对胶原诱导关节炎大鼠的免疫调控作用  

Immunoregulative Effect of Bushen Tongdu Capsule on Arthritis Rats Induced by Collagen

作　　者：林琳[1] 王英旭[2] 朱阳春[1] 周晓莉[3] 侯丽萍[1] 

机构地区：[1]北京中医药大学,北京100029 [2]太原市类风湿病医院,山西太原030006 [3]山西省中医院,山西太原030012

出　　处：《中医药学报》2014年第4期72-76,共5页Acta Chinese Medicine and Pharmacology

基　　金：太原市科技项目(编号:12016922)

摘　　要：目的:研究补肾通督胶囊对CIA大鼠的免疫调控作用。方法:将大鼠分为正常对照组、模型组、补肾通督胶囊(BS)低剂量组、中剂量组、高剂量组和雷公藤组,接受相应治疗。结果:BS对脾脏、外周血淋巴细胞有调控作用,对血清IL6和Ⅱ型胶原蛋白抗体的水平有抑制作用。结论:补肾通督胶囊对外周血淋巴细胞的调控作用效果显著。Objective： To investigate the effect of Bushen Tongdu capsules on arthritis rats induced by collagen .Methods：Rats were randomly assigned into six groups , normal control（C）, model（M）, low dose of BS（BSL）, medium dose （BSM）, high dose（BSH）,tripterygium glycosides （TG） groups and they were treated.Results： Bushen Tongdu cap-sules could relieve hyperplasia of spleen white pulp , modulate peripheral lymphocytes, IL -6 and coll -II antibody. Conclusion： Bushen Tongdu capsules are effective on modulation of peripheral lymphocyte functions .

关 键 词：补肾通督胶囊 胶原诱导关节炎 CD4 IL-6 

分 类 号：R285.5[医药卫生—中药学]