当归芍药散对实验性高脂血症模型大鼠的影响(Ⅱ)  

Effect of Danggui Shaoyao Powder on Experimental Hyperlipidemia Model Rats(Ⅱ)

作　　者：董培良[1] 张天宇[2] 殷鑫[2] 温浩[2] 曲娜[2] 韩华[2] 

机构地区：[1]黑龙江中医药大学中医药研究院,黑龙江哈尔滨150040 [2]黑龙江中医药大学药学院,黑龙江哈尔滨150040

出　　处：《中医药学报》2014年第4期102-104,共3页Acta Chinese Medicine and Pharmacology

基　　金：黑龙江省中医药管理局项目(ZHY10-Z24)

摘　　要：目的:考察当归芍药散对实验性高脂血症大鼠脂质过氧化水平及血液流变学指标的影响。方法:以高脂饲料建立高脂血症模型大鼠,观察当归芍药散干预后脂质过氧化水平及血液流变学指标的变化。结果:当归芍药散各给药组能明显减少血清中丙二醛(MDA)的含量,明显增加一氧化氮(NO)含量,升高超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)活性;红细胞压积、红细胞聚集指数显著降低,红细胞变形指数显著升高。结论:当归芍药散对高脂血症模型大鼠脂质过氧化水平及血液流变性具有一定的改善和治疗作用。Objective： To observe the effect of Danggui Shaoyao powder on lipid peroxidation level and blood rheology in -dexes of experimental hyperlipidemia rats .Method： Test the lipid peroxidation level and hemorheology index after the in -tervention of Danggui Shaoyao powder using high fat feed hyperlipidemia model rats .Results：Groups taking Danggui Shaoyao powder were obviously reduced the content of MDA , increased NO content and SOD and gsh -px activities. Meantime, red blood cells deposited, erythrocyte aggregation index decreased significantly , and erythrocyte deformation index increased significantly.Conclusion： Danggui Shaoyao powder has an improvement and treatment effect on lipid peroxidation level and blood rheology of hyperlipidemia model rats .

关 键 词：当归芍药散 高脂血症模型 血脂 血液流变学 

分 类 号：R285.5[医药卫生—中药学]