中西医结合治疗头颈部肿瘤82例患者临床疗效和不良反应探究  

Clinical Efficacy and Adverse Reaction of Chinese Medicine and Western Medicine in the Treatment of 82 Patients with Head and Neck Cancer

作　　者：杨和强[1] 何跃[1] 郭晓静[1] 余巧[1] 

机构地区：[1]成都军区总医院耳鼻喉科,四川成都610083

出　　处：《中医药学报》2014年第4期150-152,共3页Acta Chinese Medicine and Pharmacology

摘　　要：目的:探究中西医结合治疗头颈部肿瘤患者的临床疗效和不良反应,为改善头颈部肿瘤患者的临床症状提供试验依据。方法:82例患者随机分为对照组和观察组,每组各41例。两组都接受放射治疗,观察组在对照组基础上接受中药治疗。比较两组患者的疗效、卡氏评分和不良反应。结果:对照组的总有效率为73.2%,疾病控制率为82.9%。观察组的总有效率为78%,疾病控制率92.7%。观察组的总有效率、疾病控制率与对照组相比,差异不明显(χ2=1.82,0.27,P>0.05)。对照组卡氏评分有效率为75.6%,观察组卡氏评分有效率为92.7%;观察组的有效率高于对照组,差异明显,具有统计学意义(χ2=4.48,P<0.05);对照和观察组白细胞下降的发生率差异明显,具有统计学意义(χ2=4.9,P<0.05);对照组和观察组口干的发生率差异明显,具有统计学意义(χ2=4.32,P<0.05)。结论:采用滋阴解毒中药辅助放疗在疾病控制率上和总有效率上与单用放疗无明显差异,但是可以提高患者的生存质量,改善不良反应。该方案临床使用,具有一定的可行性。Objective： To explore clinical efficacy and adverse reaction of integrative medicine in the treatment of 82 pa-tients with head and neck cancer.By doing the study, we provided clinical evidence for the therapy of patients head and neck cancer.Methods： 82 patients were divided into two groups randomly .There were 41 patients in each group.Two groups were treated with radiation therapy .The observation group was given Chinese medicine on the basis of therapy in control group.The efficacy of patients, Karnofsky score and adverse reactions in two groups were compared .Results：The total effective rate of the control group was 73.2%.Disease control rate in control group was 82.9%.The total ef-fective rate of observation group was 78%.Disease control rate in observation group was 92.7%.The total detoxification combined with rate and disease control rate in two groups had no significant difference （χ2 =1.82,0.27,P ＆gt;0.05）. The effective rate of Karnofsky score in control group was 75.6%.Effective rate of Karnofsky score in observation group was 92.7%.The effective rate of Karnofsky score was higher than that of observation group .The results had a signifi-cant difference （χ2 =4.48,P ＆lt;0.05）.The incidence rate in control group and observation group had a significant difference （x2 =4.9,P ＆lt;0.05）;the incidence rate of dry mouth in control group and observation group had a significant difference（χ2 =4.32,P ＆lt;0.05）.Conclusion：Chinese medicine of nourishing Yin and detoxification combined with ra -diotherapy in the treatment of cancer and disease control rate had no difference with the single radiotherapy , but that chi-nese medicine can improve the quality of life of patients and reduce adverse reactions .The program is feasible and de-served to be applied in the clinical therapy .

关 键 词：放疗 头颈部肿瘤 中药 

分 类 号：R273[医药卫生—中西医结合]