芍药甘草汤治疗脑卒中后丘脑痛的随机、双盲临床对照研究  

“Shaoyao Gancao Decoction” for the treatment of post-stroke thalamic pain: a randomized,double-blind,placebo-controlled trial

作　　者：郭咏梅[1] 吕丹[1] 秦保锋[1] 蔡定芳[1] 

机构地区：[1]上海中医药大学附属曙光医院神经内科,上海200021

出　　处：《上海中医药杂志》2014年第7期29-32,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市卫生局中医药科研基金资助项目(2010L022A)

摘　　要：目的评价芍药甘草汤治疗脑卒中后丘脑痛的临床疗效和安全性。方法采用随机、双盲平行对照方法,将符合纳入标准的80例脑卒中后丘脑痛患者分为治疗组和对照组,每组40例。治疗组予口服加巴喷丁和芍药甘草汤颗粒剂,对照组予相同剂量的加巴喷丁及安慰剂,两组总疗程均为8周。应用简式McGill疼痛问卷评价患者疼痛的改善情况;观察中医证候情况,并比较两组的临床疗效及安全性。结果疼痛问卷评价显示,治疗组在视觉模拟评分(VAS)、疼痛分级指数(PRI)和现有疼痛强度方面(PPI)分值降低程度优于对照组(P<0.05);且在中医证候改善及总体临床疗效方面治疗组均明显优于对照组(P<0.05,P<0.01)。治疗中未见严重不良反应。结论联合应用芍药甘草汤治疗脑卒中后丘脑痛有确切的疗效,且安全性高。Objective To evaluate the clinical efficacy and safety of＂Shaoyao Gancao Decoction＂for the treatment of post-stroke thalamic pain. Methods Eighty patients with the central post-stroke pain were divided into treatment group and control group by randomized,double-blind,parallel-group method,with 40 cases in each group. Treatment group was given gabapentin and＂Shaoyao Gancao Decoction＂,and control group was treated with the same dosage of gabapentin and placebo,with the course of 8 weeks. The pain was evaluated by McGill questionnaire; the TCM symptoms were observed,and the clinical efficacy and safety were compared between the two groups. Results The MeGill pain questionnaire showed that the visual analogue scale（ VAS）,pain rating index（ PRI） and present pain intensity（PPI） were reduced in treatment group than that of the control group（ P〈0. 05）. There were significant differences in improvement of TCM symptoms and total clinical efficacy between the two groups（P〈0. 05 or P〈0. 01）. No adverse effect was found during the trial. Conclusion ＂Shaoyao Gancao Decoction＂is effective and safe in treating post-stroke thalamic pain.

关 键 词：脑卒中 丘脑痛 芍药甘草汤 

分 类 号：R277.7[医药卫生—中医学]