胸腹腔积液CYFRA21-1 NSE CA242和CEA联合测定的意义  

The combined detection significance of CYFRA21-1,NSE,CA242 and CEA in pleural effusion and ascites

作　　者：宋立兴[1] 邓清华[2] 

机构地区：[1]自贡市第四人民医院检验科,四川自贡643000 [2]泸州医学院附属医院检验科,四川泸州646000

出　　处：《西部医学》2014年第9期1232-1234,共3页Medical Journal of West China

摘　　要：目的探讨胸腹腔积液中细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、糖类抗原242(CA242)和癌胚抗原(CEA)联合测定对良恶性肿瘤的诊断、鉴别诊断以及对疗效观察的价值。方法采用化学发光法对314例不同性质的胸腹腔积液中CYFRA21-1、NSE、CA242和CEA水平进行测定并加以分析。结果在不同性质胸腹腔积液中CYFRA21-1、NSE、CA242和CEA水平均存在明显差异(均P<0.01),恶性胸腹腔积液治疗前后其CYFRA21-1、CEA、NSE和CA242测定结果均有明显差异(P<0.05),4个指标联合应用对于恶性肿瘤的诊断灵敏度达到90.8%。结论 CYFRA21-1、NSE、CA242和CEA测定对胸腹腔积液良恶性的鉴别具有重要价值,对恶性肿瘤的疗效观察也具有一定的参考价值。同时CYFRA21-1、NSE、CA242和CEA不同项目联合检测亦可提高诊断灵敏度。Objective To investigate the combined detection significance of cytokeratin 19 fragments （CYFRA21- 1）, neuron specific enolase （NSE）, carbohydrate antigen CA242 and CEA in the benign and malignant pleural effusion and ascites, for diagnosis, differential diagnosis and therapeutic evaluation. Methods M CYFRA21-1, NSE and CA242, CEA levels of different properties pleural effusion and ascites in 314 cases were measured by chemiluminescence method. Results There was obvious difference （P〈0.01） of CYFRA21-1, NSE, CA242 and CEA levels between benign and malignant of pleural effusion and ascites, also between before and after treatment. The diagnostic sensitivity of 4 parameters combination for malignant tumor achieved 90.8%. Conclusion Detecting CYFRA21-1, NSE, CA242 and CEA levels has important significance for diagnosis, differential diagnosis and therapeutic evaluation in the benign and malignant pleural effusion and ascites. The combined detection of CYFRA21-1 ,NSE,CA242 and CEA can improve diagnostic sensitivity.

关 键 词：胸腔积液 腹腔积液 CYFRA21-1 NSE A242 CEA 

分 类 号：R446.19[医药卫生—诊断学]