β-肾上腺素受体介导的G蛋白及β-arrestin依赖性通路  

G Protein-Dependent and β-Arrestin-Dependent Signaling Mediated by β-Adrenergic Receptor

作　　者：刘周英[1] 浦介麟[1] 

机构地区：[1]北京协和医学院阜外心血管病医院病理学与病理生理学研究室,北京100037

出　　处：《中国分子心脏病学杂志》2014年第4期1035-1038,共4页Molecular Cardiology of China

基　　金：国家自然科学基金项目(81273909)

摘　　要：β-肾上腺素受体所介导的经典G蛋白通路在心功能的调节中发挥着重要的作用,参与调节心肌收缩以及心肌细胞肥大等过程。近年来的研究发现,β-arrestin与β-肾上腺素受体的脱敏、内化、再循环以及降解密切相关,并可以通过其桥梁作用,使受体与多条信号通路之间建立联系。此外,β-arrestin还可以进入细胞核或者通过NF-kB/ERK进而参与表达水平的调控。鉴于β-arrestin与β-肾上腺素受体的密切关系及其本身作用的多样性,对它的深入研究将有助于新一代G蛋白偶联受体药物的研发。β-adrenergic receptor mediated classic signaling play an essential role in regulating contraction and hypertrophy of myocardium. β-arrestin were identified as mediators of G protein-coupled receptor（GPCR） desensitization, endocytosis and recycle. However, it is now clear that they integrate receptors with many intracellular signaling networks. Moreover, β-arrestin also translocate into nucleus or assist translocation of NFkB/ERK into the nucleus and activation of transcription. The involvement of arrestins in many discrete developmental signaling events suggests a potential role in the development of new types of GPCR drugs.

关 键 词：Β-肾上腺素受体 信号通路 Β-ARRESTIN 

分 类 号：R541[医药卫生—心血管疾病]