血小板生成素与急性放射病  

Thrombopoietin and acute radiation sickness

作　　者：杨萌[1,2] 欧红玲[2] 邢爽[1] 余祖胤[1] 王欣茹[2] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京100850 [2]第二炮兵总医院检验科,北京100088

出　　处：《国际药学研究杂志》2014年第4期419-423,共5页Journal of International Pharmaceutical Research

基　　金：国家自然科学基金面上项目资助(81202147)

摘　　要：巨核系造血功能障碍是导致急性放射病患者出血致死亡的主要原因之一。血小板生成素(thrombopoietin,TPO)是巨核系造血的主要刺激因子,可促进照射后巨核系造血功能恢复,升高外周血小板数。在照射后早期应用TPO对急性放射病出血并发症的防治起到关键的作用。研究表明,TPO可能具有更强促进造血恢复的作用,本文就TPO治疗急性放射病的研究进展进行综述。Megakaryocytic hematopoietic disorders is one of the leading causes of death in patients with acute radiation sickness bleeding. Thrombopoietin （TPO）,the main stimulation factor of megakaryocytopoiesis, can promote megakaryocytic hematopoietic recovery after radiation injury and increase peripheral platelet count. Early application of TPO after irradiation can play a key role in prevention and treatment of bleeding complications of acute radiation sickness. Studies have shown that TPO may have a stronger role in promoting hematopoiesis. In this paper, a brief overview of new progress on the TPO and acute radiation sickness is summarized.

关 键 词：血小板生成素 急性放射病 辐射损伤 巨核细胞 

分 类 号：R818[医药卫生—放射医学]