干粉吸入剂体内外评价技术的研究进展  

Evaluation methods in vitro and in vivo for dry powder inhalers:research advances

作　　者：李明媛[1] 梅兴国[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《国际药学研究杂志》2014年第4期432-436,443,共6页Journal of International Pharmaceutical Research

基　　金：国家"重大新药创制"科技重大专项综合性新药研究开发大平台资助项目(2012ZX09301003-001-009)

摘　　要：肺部给药已成为肺部疾病药物及某些蛋白类全身作用药物的重要给药方式。本文结合影响干粉吸入剂(DPI)性能的两大因素,即装置与微粒,就其体内、外评价体系的几种新颖的技术手段,如颗粒分布撞击器、电动力学悬浮模拟微粒与细胞表面作用的装置、液压肺技术,以及小鼠气管内吹入装置等进行了重点阐述,为DPI的研究与开发提供评价技术方面的参考。Drug delivery to lungs is becoming an important means of administration of some drugs for lung disease and some protein drugs with systemic effects. This article introduces the inhalation devices and particle characteristics,the two main features of dry powder inhalers （DPI）, then reviews the advances on evaluation methods in vitro and in vivo for DPI, such as next generation pharmaceutical impactor （NGI）, the imitation between particles and cells using electrodynamic levitation, hydraulic lung and dry powder endotracheal insufflator device, providing references for research and development of DPI evaluation methods.

关 键 词：干粉吸入剂 评价技术 新型颗粒分布撞击器 电动力学悬浮 液压肺 气管内吹入装置 

分 类 号：R94[医药卫生—药剂学]