胰腺癌320排容积CT全胰腺灌注分析  

Initial Experience of Whole Pancreas Perfusion Imaging with 320-Slice CT in Pancreatic Cancer

作　　者：关静[1] 杜飞舟[1] 顾明[1] 李建浩[1] 张媛[1] 

机构地区：[1]成都军区总医院医学影像科,四川成都610083

出　　处：《四川医学》2014年第8期944-946,共3页Sichuan Medical Journal

基　　金：四川省卫生厅科研课题(编号:090007)

摘　　要：目的利用320排容积CT对胰腺癌患者进行全胰腺灌注分析,探讨胰腺癌病灶与其周围正常胰腺组织灌注特征。方法利用320排动态容积CT对25例胰腺癌患者进行全胰腺灌注扫描,测量并比较胰腺癌及周围相对正常胰腺组织的血流量（AF）、达峰时间（TTP）,对比分析病灶与周围组织的灌注差异。并统计身体质量指数（BMI）为22.0~24.0kg/m2时的放射剂量。结果胰腺癌病灶AF（49.95±19.29）（ml/min/100ml）明显低于周围正常胰腺组织[正常胰头：（134.18±35.39）;正常胰体：（138.81±51.72）;正常胰尾：（137.39±43.60）;胰腺癌TTP（50.80±4.81）s较周围正常胰腺组织（正常胰头：（21.35±5.51）;正常胰体：（21.99±7.07）;正常胰尾：（23.11±7.30）]延长,差异有统计学意义（P〈0.05）。而正常胰腺组织头、体、尾部组间AF及TTP无统计学差异（P〉0.05）。统计身体质量指数（BMI）为22.0~24.0kg/m2时放射剂量约为（18.6±2.4）mSv。结论 320排动态容积CT胰腺灌注成像能够准确反映出胰腺癌及周围正常胰腺组织的血流灌注特点,在临床上对胰腺癌的诊断与治疗评估具有重要价值。Objective To study the value of perfusion imaging with 320-slice CT in diagnosis of pancreatic cancer and compare the perfusion parameters between pancreatic cancer and normal tissue in the same patient. Methods 25 patients with pancreatic cancer underwent CT perfusion on a 320-slice CT of Toshiba Aquilion one body perfusion software and the perfusion characteristic parameters（including AF,T1P）were compared. Results Pancreatic cancer showed higher TIP and lower AF com- pared with those of normal tissue in the same patient （ P 〈 0. 05 ）. Conclusion 320-slice CT perfusion is a feasible technique to assess pancreatic blood perfusion. Comparison of perfusion parameters of pancreatic cancer and normal tissue of the same patient can be a good option in the diagnosis of pancreatic cancer. Permeability can assess the degree of blood vessels destruction.

关 键 词：胰腺癌 体层摄影技术 灌注成像 

分 类 号：R735.9[医药卫生—肿瘤]