p53与TGF-β通路相关性的研究进展  

Research Advances on the Relationship between p53 and TGF-β Signalling

作　　者：马远娜 王允山[3,2] 吉爱国[1,3,2] 

机构地区：[1]山东大学药学院,山东济南250012 [2]山东大学威海国际生物技术研发中心,山东威海264209 [3]山东大学海洋学院,山东威海264209

出　　处：《药物生物技术》2014年第4期359-362,共4页Pharmaceutical Biotechnology

基　　金：国家自然科学基金资助项目(No.30873198)

摘　　要：转录调节因子p53作为一种抑癌基因,可诱导细胞生长阻滞、凋亡、分化以及DNA修复。突变型p53丧失了野生型p53的正常功能,能促进细胞增殖转化而且具有致癌作用。TGF-β超家族信号通路广泛参与胚胎发育,细胞增殖、分化、迁移和凋亡,创伤修复。P53与TGF-β通路之间有着广泛的联系,同时二者在肿瘤等疾病中都有着重大的作用。文章研究了p53与TGF-β通路之间的联系以及在某些生物学中的功能。The tumor suppressor gene p53 is a transcription factor that mediates several cellular processes including growth arrest, apoptosis ,differentiation and DNA damage repair. At the same time, mutant p53 generally subverts TGF-[3 responses, diminishing transcriptional activation of key TGF-β target genes. Mutant p53 can also interact with Smads, which enables complex formation with the p53 family member p63 and blocks p63-mediated activation of metastasis suppressing genes to promote tumour progression. TGF-β is an important regulator for human, which plays important roles in embryonic development, cell growth, differentiation, migration and apoptosis. P53 has a close correlation with TGF-β signalling pathway . Wild-type p53 and TGF-β are key tumour suppressors regulate an array of cellular responses. They play important roles in the occurrence and development of carcinoma. Accurately under- standing the regulatory relationship between p53 and TGF-β signalling and the potential roles it plays in some biological function ,will help us recognize the process of some diseases development, and eventually help us to cure them.

关 键 词：转录调节因子 P53 胚胎发育 细胞增殖 凋亡 肿瘤 生物学功能 

分 类 号：Q74[生物学—分子生物学]