光敏感型嵌段聚合物胶束的研究进展  

Progress in photo-responsive block copolymer micelles

作　　者：余丽丽[1,2] 汤新景[2] 

机构地区：[1]西安医学院药学院,陕西西安710021 [2]北京大学医学部药学院天然药物及仿生药物国家重点实验室,北京100191

出　　处：《化工进展》2014年第9期2372-2379,共8页Chemical Industry and Engineering Progress

基　　金：国家自然科学基金青年项目(81302706);教育部高等学校新教师基金(20100001120051);陕西省教育厅科研计划(2013JK0759);北京大学天然药物及仿生药物国家重点实验室开放基金(K20120212)项目

摘　　要：对聚合物结构中常见的光敏感性基团进行了介绍,并根据嵌段共聚物结构设计和光敏感基团的差异,将光敏感型嵌段聚合物胶束(BCPM)分为侧链变化型、主链断裂型、主链降解型和疏水交联型等几类,并对这几类BCPM的结构特征及其光刺激下结构的变化进行了对比分析,重点阐明了各类BCPM作为药物载体材料时对药物的光控包载或释放行为。光敏感型BCPM具有良好的结构可控性和刺激响应能力,通过结构的进一步优化和研究的不断深入将有望发展成为一类新型的药物靶向输送系统。The common group of photo-responsive moieties was introduced in this paper. According to the block copolymer structure and the particularity of photo-responsive moieties,the photo-responsive block copolymer micelles （BCPM） were divided into four kinds,which are side chain change,main chain rupture,main chain degradation,and hydrophobic cross-linking. In addition,the characteristics of these BCPM and the light stimuli structure changes of these micelles were reviewed. Particular attention is paid to light-dependent drug loading process and drug release behavior for drug delivery. Through further structure optimization and research,some photo-responsive BCPM is expected to develop into a new type of drug targeting delivery system , because of its excellent structure controllability and stimulus response ability.

关 键 词：光敏感 嵌段共聚物 胶束 纳米粒子 

分 类 号：O631.1[理学—高分子化学]