缺血后适应及药物后处理对心肌缺血再灌注损伤的保护作用  

Protective Effect of Ischemia Post Conditioning and Pharmacologic Post Conditioning on Myocardial Ischemia and Reperfusion

作　　者：张文婷[1] 王晓元[1] 李方江[2] 

机构地区：[1]河北北方学院研究生部,河北张家口075000 [2]河北北方学院第一附属医院心血管内科,河北张家口075000

出　　处：《医学综述》2014年第16期2903-2906,共4页Medical Recapitulate

基　　金：张家口市科技局指令性科研课题(12110044D-2)

摘　　要：随着冠状动脉粥样硬化性心脏病患者的增加及与之相关的再灌注治疗的开展,心肌缺血再灌注损伤(MIRI)成为临床心脏病学面临的严峻挑战。心肌缺血/再灌注后施加不同的后处理方式,可有效抵抗MIRI。缺血后适应及药物后处理是对缺血再灌注损伤具有保护作用的主要的后处理方式,该文将对这两类后处理方式的研究进展予以综述。Myocardial ischemia reperfusion injury （MIRI） has become a severe challenge in clinical cardiology with the increase of coronary heart disease and the development of associated reperfusion therapy in recent years. Different approaches can be applied to effectively resist MIRI after myocardial ischemia and reperfusion. Ischemic post conditioning and pharmacologic post conditioning are main post conditioning approaches with protective effect on MIRL Here is to summarize the research progress of the two types of post conditioning approaches.

关 键 词：缺血 再灌注 心肌缺血再灌注损伤 缺血后适应 药物后处理 

分 类 号：R541.4[医药卫生—心血管疾病]