血清淀粉样蛋白A与不同糖耐量人群血管内皮功能的关系探讨  

Level of serum amyloid A and its relationship to vascular endothelial function in patients with different glucose intolerance

作　　者：熊晓清[1] 赖美铮[1] 张扬[1] 冯琼[1] 

机构地区：[1]暨南大学第四附属医院广州市红十字会医院内分泌科,510220

出　　处：《国际医药卫生导报》2014年第17期2632-2635,共4页International Medicine and Health Guidance News

基　　金：广州市医药卫生科技项目（20121A011051）

摘　　要：目的探讨不同糖耐量人群血清淀粉样蛋白A的水平，及与血管内皮功能的关系。方法59例患者根据OGIT试验分为3组：19例NGT、20例IGT和20例T2DM。分别检测血清淀粉样蛋白A、生化指标、肱动脉内皮依赖性舒张功能（FMD）和含服硝酸甘油后肱动脉内皮依赖性舒张功能（NID）。结果①SAA随着血糖的升高而升高，DM组的SAA较IGT组、NGT组明显升高（P〈0．01），IGT组的SAA较NGT组升高（P〈0．05）。②FMD随着SAA的升高而下降，DM组的FMD较IGT组和NGT组明显降低（P〈0．01），IGT组的FMD较NGT组降低（P〈0．05）。③Spearman相关分析显示SAA与FBG、HbA1c、TC均呈正相关（r值分别为0．63、0．48、0．59，P〈0．01），与FMD呈显著负相关（r值为-0．62，P〈0．01）。结论SAA与血管内皮功能损害密切相关。Objective To investigate the level of serum amyloid A in patients with different glucose intolerance, and its correlation with vascular endothelial function. Methods 59 cases were divided into three groups by oral glucose tolerance test （OGTT）：19 cases of normal glucose tolerance （NGT）, 20 cases of impaired glucose tolerance （IGT） and 20 cases of type 2 diabetes （DM）. Serum amyloid A and other biochemical indices were measured. Color Doppler examination was followed to evaluate flow-mediated vasodilation （FMD）, nitroglycerin vasodilation （NID）. Results ① SAA was increased with the increment of Glucose. In DM group, SAA was higher than that in IGT group and NGT group（P 〈 0.05）, while the difference between IGT group and NGT group was also significant （P 〈 0.05）. ② FMD was significantly decreased in contrast to the increment of SAA, in DM group, FMD was lower than that in IGT group and NGT group（P 〈 0.05）, while the difference between IGT group and NGT group was also significant（P 〈 0.05）. ③） Spearman regressive analysis showed that SAA was positively related to FBG, HbAlc, TC （r=0.63, 0.48, 0.59, P 〈 0.001）, while negatively with FMD （r=-0.62, P 〈 0.001）. Conclusion SAA is closely related to vascular endothelial dysfunction.

关 键 词：血清淀粉样蛋白A 糖耐量 血管内皮功能 

分 类 号：R446.1[医药卫生—诊断学]