冠心病合并2型糖尿病患者profilin-1、晚期糖基化终产物受体水平及临床意义  

The levels and clinical significance of profilin-1,RAGE in patients with CHD combined with type 2 DM

作　　者：杨达峰[1] 马丽平[1] 杨天伦[1] 谢秀梅[2] 陈美芳[2] 

机构地区：[1]中南大学湘雅医院心内科,长沙410008 [2]中南大学湘雅医院老干科,长沙410008

出　　处：《临床心血管病杂志》2014年第8期685-687,共3页Journal of Clinical Cardiology

基　　金：国家自然科学青年基金(No:81000140);中南大学自由探索计划青年教师助推项目(No:1801725)

摘　　要：目的:检测冠心病(CHD)及冠心病合并糖尿病(DM)患者血浆中profilin-1、晚期糖基化终产物受体(RAGE)的水平,并进一步探讨其临床意义。方法:入选89例研究对象,其中对照组27例,CHD组31例,CHD合并DM组31例。空腹采集外周静脉血,采用ELISA法检测血浆profilin-1与RAGE水平;收集一般临床资料及常规生化指标,根据Gensini积分系统计算冠状动脉(冠脉)狭窄程度。结果:1CHD组和CHD合并DM组患者血浆profilin-1及RAGE水平以及Gensini积分明显高于对照组(P<0.05),CHD合并DM组更为明显(P<0.05);2血浆profilin-1水平与RAGE水平呈正相关(R2=0.716 1,P<0.05),血浆profilin-1、RAGE水平与Gensini积分呈正相关(R2=0.749 4、0.842 4,P<0.05)。结论:CHD合并2型DM患者血浆profilin-1与RAGE水平明显高于单纯CHD患者,且profilin-1与RAGE水平与Gensini积分呈正相关,提示血浆profilin-1与RAGE水平可在一定程度上反映冠脉狭窄程度。Objective.. To investigate the levels and possible clinical significance of profilin-1, receptor for ad- vanced glycation end products （RAGE） in the patients with coronary heart disease （CHD） and CHD companied with diabetes mellitus （DM）. Method： A total of 89 patients were enrolled in this study including 27 individuals in control group, 31 individuals in CHD group and 31 patients in CHD ＋ DM group. Plasma levels of profilin-1 and RAGE were determined by ELISA, and the degree of coronary stenosis was calculated according to the Gensini scoring system. Result：①Plasma levels of profilin-1, RAGE and Gensini scores were significantly higher in CHD or CHD ＋ DM group than those in control control （P〈0.05）, especially higher in CHD＋DM group. ②The levels of profilin-1 were positively correlated with the levels of RAGE or Gensini scores （R2=0. 716 1, 0. 749 4, both P〈0.05）, plasma levels of RAGE were also positively correlated with Gensini scores （R2=0. 8424, P〈0.05）. Conclusion.. The levels of profilin-1 and RAGE in patients with CHD and DM are significantly higher than those with CHD, and the levels of profilin-1 and RAGE are positively correlated with Gensini scores, suggesting that the levels of profilin-1 and RAGE may reflect coronary artery stenosis to some extent.

关 键 词：冠心病 糖尿病 profilin-1 晚期糖基化产物受体 GENSINI积分 

分 类 号：R541.4[医药卫生—心血管疾病]