超声微泡介导川芎嗪干预兔髂动脉损伤后血管再狭窄的可行性  

Effects of TMP mediated by ultrasound-targeted microbubbles destruction on vessel stenosis in rabbits' iliac artery after balloon-injury

作　　者：耿化晓 计晓娟[1] 余更生[1] 郭军[2] 杨汝铃[1] 谢军[1] 

机构地区：[1]重庆医科大学附属儿童医院心脏中心儿童发育疾病研究省部共建教育部重点实验室儿科学重庆市重点实验室重庆市儿童发育重大疾病诊治与预防国际科技合作基地,重庆400014 [2]绵阳市中心医院

出　　处：《临床心血管病杂志》2014年第8期718-721,共4页Journal of Clinical Cardiology

基　　金：国家自然科学基金青年基金资助项目(No:81301300);重庆市卫生局课题(No:2011-2-242)

摘　　要：目的:探讨超声微泡介导川芎嗪对兔髂动脉球囊损伤后内膜增生和血管狭窄的影响。方法:25只雄性新西兰大白兔,体重(2.2±0.1)kg,随机分为5组,每组5只。A组:空白组;B组:模型组;C组:超声微泡介导川芎嗪术后即刻给药组;D组:超声微泡介导川芎嗪术后1周给药组;E组:超声微泡介导川芎嗪术后3周给药组。各治疗组连续干预7d。术后4周取损伤处髂动脉HE染色测量内中膜面积比和狭窄率。结果:与A组相比,B组内中膜面积比和狭窄率增大(P<0.01)。与B组相比,C组和D组内中膜面积比和狭窄率均显著减少(均P<0.05),C组下降最明显;E组内中膜面积比减少(P<0.05),管腔面积和狭窄率变化不大。结论:超声微泡介导川芎嗪可显著抑制兔髂动脉球囊损伤后内膜增生和血管狭窄,早期干预效果显著。Objective：To estimate the effects of TMP mediated by ultrasound-targeted microbubbles destruc- tion on intimal hyperplasia and vessel stenosis in rabbits＇ iliac artery after balloon-injury. Method：Twenty five New Zealand white male rabbits, weighted （2.2 ±0.1） kilogram, were divided into five group （n = 5）, A group ： sham group; B group： model group; C group.. TMP mediated by uhrasound-targeted microbubbles destruction interfer- ence at 0 day after injury; D group： TMP mediated by ultrasound-targeted microbubbles destruction interference at 1 week after injury; E group： TMP mediated by ultrasound-targeted microbubbles destruction interference at 3 weeks ~.fter injury. Intimal hyperplasia and stenosis rate were examined with pathology after artery balloon-injury 4 weeks. Result：Intima-media ratio and stenosis rate in group B was larger than that in group A （P〈0.01）. Inti- ma-media ratio and stenosis rate in group C and group D were found lower than group B（both P〈0.05）. Al- though intimal-media ratio in group E was smaller than that in group B（P〈0.05）, stenosis rate was similar to group B. Conclusion：TMP mediate by ultrasound-targeted microbubbles destruction can inhibit intimal hyperplasia and vessel stenosis in rabbits iliac artery after balloon-injury, interference earlier will have better effect.

关 键 词：微泡 川芎嗪 兔 再狭窄 

分 类 号：R541[医药卫生—心血管疾病]