BDNF、VEGF与2型糖尿病颈动脉粥样硬化的相关性  

Relationship of carotid atherosclerosis with serum brain-derived neurotrophic factor and vascular endothelial growth factor in type 2 diabetes mellitus patients

作　　者：邱世超[1] 任建功[1] 罗晖[1] 胡雪剑[1] 侯园花 

机构地区：[1]兰州大学第二医院糖尿病二科,兰州730030

出　　处：《第二军医大学学报》2014年第8期920-923,共4页Academic Journal of Second Military Medical University

摘　　要：目的探讨血清脑源性神经营养因子(BDNF)、血管内皮生长因子(VEGF)与2型糖尿病(T2DM)颈动脉粥样硬化的关系。方法收集兰州大学第二医院糖尿病二科收治住院的T2DM患者120例,依据颈动脉彩色多普勒超声显像分为合并颈动脉粥样硬化组64例和非颈动脉粥样硬化组56例。另收集同期体检中心健康体检者60例为对照。收集患者临床资料,并使用ELISA法测定血清BDNF、VEGF浓度。结果健康对照组、非颈动脉粥样硬化组、合并颈动脉粥样硬化组血清BDNF水平[(9.97±2.59)、(6.88±3.10)、(5.62±3.41)ng/mL]逐渐降低,差异有统计学意义(P<0.05);三组血清VEGF水平[(49.29±20.23)、(61.29±22.05)、(71.34±20.30)pg/mL]逐渐升高,差异具有统计学意义(P<0.05)。结论 T2DM合并颈动脉粥样硬化患者血清BDNF水平降低、VEGF水平升高,提示血清低浓度BDNF及高浓度VEGF共同参与颈动脉粥样硬化的发生及发展。Objective To investigate the relationship between carotid atherosclerosis and serum brain-derived neurotrophic factor （BDNF） , vascular endothelial growth factor （VEGF）levels in patients with type 2 diabetes mellitus （T2DM）. Methods A total of 120 T2DM patients who were treated in our hospital were assigned to non-carotid atherosclerosis group （n=56） and the carotid atherosclerosis group （n= 64） according to the results of carotid artery ultrasound detection. Another 60 healthy controls were recruited from health check-up populations. Clinical data of the participants were collected, and their serum levels of BDNF, VEGF were determined by ELISA. Results The serum BDNF levels of health check-up populations, non-carotid atherosclerosis group, and carotid atherosclerosis group were （9.97± 2.59） ng/mL, （6.88 ± 3. 10） ng/mL,and （5.62±3.41）ng/mL, respectively, showing significant difference between different groups （P〈0.05） ; the serum VEGF levels were （49.29±20.23） ng/mL, （61.29±22.05） ng/mL, and（71.34±20.30）pg/mL, respectively, also showing significant difference between different groups （P〈0.05）. Conclusion T2DM patients complicated with carotid atherosclerosis have deceased serum BDNF level and increased VEGF level, suggesting that low level of BDNF and high level of VEGF may be involved in the occurrence and progression of carotid atherosclerosis.

关 键 词：2型糖尿病 颈动脉疾病 动脉粥样硬化 脑源性神经营养因子 内皮生长因子 

分 类 号：R587.23[医药卫生—内分泌]