Kisspeptins/GPR54神经内分泌系统对哺乳动物生殖活动的调控  

Kisspeptins/GPR54 System and Reproduction Regulation in Mammal

作　　者：张伟[1,2,3] 王世银[1] 甘尚权[2] 石国庆[2] 

机构地区：[1]新疆农业职业技术学院,昌吉831100 [2]新疆农垦科学院畜牧兽医研究所,石河子832000 [3]石河子大学动物科技学院,石河子832003

出　　处：《中国细胞生物学学报》2014年第8期1200-1206,共7页Chinese Journal of Cell Biology

基　　金：新疆农业职业技术学院科研项目(批准号:XJNZYKJ2013008;XJNZYKJ2013010);国家自然科学基金(批准号:31360540)资助的课题~~

摘　　要：哺乳动物的生殖活动受到神经内分泌系统的精确调控。近年来的研究表明,KISS-1基因的表达产物Kisspeptins及其G蛋白偶联受体(G protein coupled receptor 54,GPR54)在这一调控网络中发挥着重要作用,与哺乳动物青春期启动、发情排卵及季节性繁殖等过程密切相关。该文就近年来Kisspeptins/GPR54系统对哺乳动物生殖活动调控的研究进展进行简述。The reproduction of mammal is controlled by a network which composed of neuro-endocrine system. The recent research has demonstrated that Kisspeptins, the protein of KISS-1 gene, and its receptor GPR54 play important roles in this neuro-endocrine network, and have intimate relationship with the onset of puberty, oestrus and ovulation, the switching of oestrus and anestrus of seasonal reproduction animal. Here, the recent research progress of Kisspeptins/GPR54 system in the mammal reproduction regulation is reviewed.

关 键 词：Kisspeptins GPR54 KISS-1 生殖调控 

分 类 号：Q492[生物学—生理学]