GAG、MDA检测在非霍奇金淋巴瘤诊疗中的临床意义  

The clinical significance of GAG and MDA detections in the diagnosis and treatment of non-Hodgkin's lymphoma

作　　者：张煜[1] 江铭磊[1] 卢仁泉[1] 郭林[1] 

机构地区：[1]复旦大学附属肿瘤医院复旦大学上海医学院肿瘤学系,上海200032

出　　处：《检验医学》2014年第9期889-892,共4页Laboratory Medicine

摘　　要：目的探讨葡糖氨基葡聚糖(GAG)、丙二醛(MDA)在非霍奇金淋巴瘤(NHL)中的诊疗价值。方法利用酶联免疫吸附试验(ELISA)测定99例NHL患者和58名健康对照者的血清GAG、MDA水平,对其中20例滤泡型淋巴瘤(FL)患者化疗效果进行随访监测,并对测定结果用非参数秩和检验进行分析比较。结果 99例NHL患者血清中GAG和MDA水平显著高于正常对照组(P<0.01),且在FL患者中升高尤为显著(P<0.01)。20例FL患者随访测定GAG水平与疾病进展情况基本一致(符合率>75%),而MDA的变化率与病情并不完全一致。结论 GAG和MDA在NHL诊断和疗效监测中有较好的临床应用价值。Objective To investigate the significance of glycosaminoglycan( GAG) and malondialdehyde( MDA)in the diagnosis and treatment of non-Hodgkin' s lymphoma( NHL). Methods Enzyme-linked immunosorbent assay( ELISA) was used to detect the levels of serum GAG and MDA in 99 NHL patients and 58 healthy controls. The chemotherapy efficiency in 20 follicular lymphoma( FL) patients were followed and monitored,and the results were analyzed and compared by nonparametric rank sum test. Results The levels of serum GAG and MDA in 99 NHL patients were significantly higher than those in healthy controls( P < 0. 01),especially in FL patients( P < 0. 01). The progress of GAG level in 20 followed-up FL patients was consistent with disease progression( consistency rate > 75%),while the progress of MDA level was not entirely consistent with disease progression. Conclusions GAG and MDA have a useful clinical application significance in the diagnosis and treatment monitoring of NHL.

关 键 词：葡糖氨基葡聚糖 丙二醛 非霍奇金淋巴瘤 

分 类 号：R446.6[医药卫生—诊断学]