不同剂量布地奈德混悬液氧气雾化对慢性阻塞性肺疾病的疗效比较  

Comparison of the efficacy of different dose nebulized budesonide in treatment of chronic obstructive pulmonary disease

作　　者：王梦芝[1] 佘德宇 卢淑玲[1] 

机构地区：[1]广东省东莞市长安医院药剂科,广东东莞523843

出　　处：《中国医药科学》2014年第16期12-15,22,共5页China Medicine And Pharmacy

基　　金：广东省东莞市医疗卫生单位科技计划一般项目(201110515022198)

摘　　要：目的：探讨不同剂量布地奈德混悬液氧气雾化对慢性阻塞性肺疾病的疗效比较，旨在提高治疗效果。方法收集2011年4月～2013年11月我科住院的420例稳定期COPD患者及330例急性加重期COPD患者，将稳定期慢性阻塞性肺疾病（COPD）患者分为中等剂量组、小剂量组、对照组。急性加重期慢性阻塞性肺疾病（AECOPD）患者被分为大剂量组、中剂量组、一般剂量组以及对照组。对比分析各组间的治疗效果、肺功能和生活质量。结果稳定期患者治疗后中等剂量组、小剂量组呼吸困难评分与对照组比较评分均明显改善（P＜0.05），中等剂量组FEV1、FEV1/FVC（%）与小剂量组与对照组比较差异有统计学意义（ P＜0.05）。患者生活质量评分中等剂量组、小剂量组与对照组比较差异有统计学意义（P ＜0.05）。AECOPD患者在治疗5、10d后三组肺功能均有明显改善，不同剂量组间均有显著性差异（P＜0.05）。结论对于稳定期COPD应用小剂量布地奈德雾化治疗，疗效肯定，无明显毒副作用，可以临床推广。急性发作期COPD，应用大剂量布地奈德雾化吸入可以使肺功能改善更快更好，且临床应用安全有效。ObjectiveTo investigate the efficacy of different doses budesonide on chronic obstructive pulmonary disease, aimed at improving the therapeutic effect.Methods420 stable COPD patients and 330 cases of acute COPD patients treated in our hospital from 2011.04 to 2013.11 were enrolled. the stable COPD patients were divided into moderate doses group, low-dose group and the control group . The AECOPD patients were divided into high-dose group, middle dose group, generally dose group and the control group. Comparative analysis of the therapeutic effect, pulmonary function and quality of life in different groups.Results The dyspnea scores of stable patients in moderate-dose group and low-dose group were significantly improved compared with control group （P〈0.05）. the difference of FEV1 and FEV1/FVC% in medium- dose group, low dose group and the control group was statistically significant after treatment （P〈0.05） . The difference of QOL scores was statistically significant in moderate dose group, low -dose group and the control group （P〈0.05）. The lung function of AECOPD patients in three groups showed significant improvement after treatment of 5 days and 10 days （P〈0.05）.Conclusion For stable COPD patients, small dose of budesonide was more effective, without significant side effects, can be widely used clinical. For AECOPD, large doses of budesonide inhalation can make faster and better improvement in lung function. And it is safe and effective in clinical application.

关 键 词：布地奈德 慢性阻塞性肺疾病 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]