腹腔镜术后联合米非司酮治疗子宫内膜异位症临床研究  

Clinical research on the laparoscopic surgery combined with low-dose mifepristone in treatment of endometriosis

作　　者：张巧仪[1] 罗建华[1] 张建飞[1] 陈秋妍[1] 

机构地区：[1]广东省东莞市妇幼保健院妇产科,广东东莞523000

出　　处：《中国医药科学》2014年第16期197-198,201,共3页China Medicine And Pharmacy

摘　　要：目的探讨腹腔镜术后联合低剂量米非司酮治疗子宫内膜异位症周期及临床疗效。方法选取我院收治的66例子宫内膜异位症患者作为研究对象,随机均分为A、B、C三组,A组采用腹腔镜术后米非司酮治疗,B组采用术后孕三烯酮胶囊治疗,C组术后不予以任何辅助药物治疗,比较三组1年内复发率、缓解率、妊娠率、月经恢复时间及排卵恢复时间。结果三组缓解率差异比较无统计学意义(P>0.05),复发率及妊娠率比较差异有统计学意义(P<0.05);A组复发率明显低于B组及C组,妊娠率高于B组及C组,差异有统计学意义(P<0.05);A组及C组月经恢复时间及排卵恢复时间明显短于B组,差异比较有统计学意义(P<0.05)。结论采用腹腔镜术后联合低剂量米非司酮短期疗法治疗子宫内膜异位症有助于缩短月经及排卵恢复时间,提高受孕率,降低复发率,临床疗效显著,值得在临床上推广应用。ObjectiveTo evaluate the clinical efficacy of laparoscopic surgery combined with low-dose mifepristone treatment of endometriosis.Methods66 patients with endometriosis in our hospital were randomly divided into A group,B group,C group.A group was given laparoscopic surgery mifepristone treatment,and B group was given gestrinone capsule treatment,and C group wasn＇t given any secondary therapy.The recurrence rate within 1 year,response rate,pregnancy,menstruation and ovulation recovery time of three groups were compared. Results There was no statistically significant difference in response rates of three groups （P〉0.05）,and there were significant differences in relapse rate and pregnancy rate（P〈0.05）.The recurrence rate of A group was significantly lower than that of group B and group C,and the pregnancy rate was higher than that of group B and group C, and there was more significant different（P〈0.05）.The recovery time of menstruation and ovulation recovery time in A group and group C were significantly shorter than those of group B,and the differences were statistically significant（P〈0.05）. ConclusionLaparoscopic surgery combined with low-dose mifepristone short-term therapy for endometriosis can help short recovery time of menstruation and ovulation,improve the pregnancy rate,and reduce the relapse rate. It＇s significant clinical efficacy,worthy of clinical application.

关 键 词：腹腔镜 低剂量 米非司酮 子宫内膜异位症 临床疗效 

分 类 号：R713[医药卫生—妇产科学]