保肾颗粒对家兔C-BSA异种血清免疫复合型肾炎模型的影响  

The effects of Baoshen granule on C-BSA heterologous serum' immune complex glomerulonephritis in rabbits

作　　者：林波[1] 刘宇[1] 向丽[1] 韦婷[1] 张祎[1] 曾勇[1] 孟宪丽[1] 

机构地区：[1]成都中医药大学药学院中药材标准化教育部重点实验室中药资源系统研究与开发利用省部共建国家重点实验室培育基地,成都610037

出　　处：《中药药理与临床》2014年第3期121-123,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:观察复方保肾颗粒对兔C-BSA异种血清免疫复合型肾炎模型的影响。方法:连续6周给家兔耳缘静脉注射阳离子化牛血清白蛋白制得肾炎模型,将动物分为空白对照组、模型对照组、复方保肾颗粒1.2g/kg、0.6 g/kg、0.3 g/kg剂量组、醋酸地塞米松组,灌胃给药10周后,检测动物尿蛋白、血清肌酐、尿素氮浓度及肾脏病理变化等指标的变化。结果:保肾颗粒能明显降低C-BSA肾炎模型家兔的尿蛋白、血清肌酐及尿素氮浓度,减轻肾脏的病理损伤。结论:复方保肾颗粒对C-BSA型肾炎家兔具有一定的保护和治疗作用。Objective： Observed Fufangbaoshen granule therapy influenced on the C-BSA Heterogeneous serum immune of complex nephritis rabbit.Method： Continuously injected C-BSA on the rabbits’ ear vein for 6 weeks to make rabbit get nephritis,then divided into 6 groups： normal control group,model group,fufangbaoshen granule 1. 2g /kg,0. 6 g /kg,0. 3 g /kg group,dexamethasone group. After 10 weeks Gavage administration,then tested urine protein,CR,BUN and kidney pathological change of rabbit. Result： Fufangbaoshen granule could not only significantly decrease urine proteins,CR and BUN,but can mitigates the pathological damage in rabbits’ kidneys. Conclusion： fufangbaoshen granule can make better effect treatment on nephritis rabbit.

关 键 词：保肾颗粒 慢性肾炎 C-BSA 尿蛋白 肌酐 尿素氮 

分 类 号：R285[医药卫生—中药学]