Hallmarks of triple negative breast cancer emerging at last？  

作　　者：Rosa Bemardi Luca Gianni 

机构地区：[1]Division of Molecular Oncology, San RaffaeleScientific Institute, San Raffaele Hospital, 20132 Milan, Italy [2]Department of Medical Ontology, San Raffaele Hospital, 20132 Milan, Italy

出　　处：《Cell Research》2014年第8期904-905,共2页细胞研究（英文版）

摘　　要：Triple negative breast cancers （TNBC） are clinically heterogeneous but mostly aggressive malignancies devoid of expression of the estrogen, progesterone and HER2 （ERBB2 or NEU） receptors. Recent evidence shows that basal endoplasmic reticulum stress （ERS） is typically activated in TNBC and cooperates with hypoxia signaling to promote tumor progression and relapse; ERS and hypoxia response may therefore be among the long-searched hallmarks of TNBC.

关 键 词：乳腺癌 阴性 恶性肿瘤 ERBB2 内质网应激 ERS 异质性 雌激素 

分 类 号：Q64[生物学—生物物理学] S858.292[农业科学—临床兽医学]