生长激素缺乏矮小儿童垂体病变的3.0T MRI 研究  

3.0T MRI study of pituitary lesions in children with short stature caused by growth hormone deficiency

作　　者：贾秀川[1] 李宝山[1] 何磊[1] 孙吉林[1] 

机构地区：[1]河北省人民医院医学影像科,河北石家庄050051

出　　处：《实用放射学杂志》2014年第8期1355-1357,共3页Journal of Practical Radiology

摘　　要：目的：观察生长激素缺乏（GHD）矮小儿童垂体病变的 MRI 特点。方法回顾性分析经临床、病理证实的 GHD 矮小儿童各种垂体病变40例，所有病例均行3.0T MRI 检查。结果 GHD 矮小儿童各种垂体病变包括垂体前叶发育不良25例，垂体柄阻断综合征3例，颅咽管瘤术后2例，垂体增生10例。垂体前叶发育不良表现为垂体前叶高度小于正常值；垂体柄阻断综合征除垂体前叶发育不良外，尚可见垂体柄缺如或明显变细，垂体后叶 T1 WI 高信号异位；颅咽管瘤术后可见垂体萎缩变薄，垂体柄显示不清；垂体增生由甲状腺功能减退所致，表现为垂体前叶体积增大，上缘对称性隆起，垂体柄未见推移、中断及异常信号，增强扫描呈明显均匀强化，替代治疗后垂体体积缩小。结论 MRI 能够准确显示 GHD 矮小儿童各种垂体病变的特点，与临床相结合可以准确诊断，并可监测其治疗效果。Objective To study the MRI features of pituitary lesions in children with short stature caused by growth hormone deficiency.Methods The MRI findings of clinical and pathological confirmed pituitary lesions in 40 children were retrospectively reviewed.All cases had 3.0T MRI examination.Results The pituitary lesions included hypoplasia of antehypophysis （25 cases）,pituitary stalk interruption syndrome （3 cases）,pituitary atrophy after craniopharyngioma excision （2 cases）and pituitary hyperplasia （10 cases）.MRI of antehypophysis hypoplasia showed that the height of antehypophysis was less than normal.Pituitary stalk inter-ruption syndrome showed not only hypoplasia of antehypophysis,but also absence or marked thinning of pituitary stalk and ectopic bright signal of posterior pituitary lobe on T1 WI.Atrophy of the pituitary was seen after resection of craniopharyngioma,and the stalk was unclear.All of the pituitary hyperplasia were caused by hypothyroidism.MRI of pituitary hyperplasia displayed antehy-pophysis enlargement and upward apophysis symmetrically.There were no pituitary stalk interruption,translocation and abnormal signal.The pituitary hyperplasia had obvious homogeneous enhancement.Pituitary gland reduced in size after replacement therapy. Conclusion MRI can show the features of pituitary lesions in children with short stature caused by growth hormone deficiency clearly.Correct diagnosis can be made and the therapeutic effect can be monitored combining with clinical manifestation.

关 键 词：生长激素缺乏 垂体 磁共振成像 

分 类 号：R584[医药卫生—内分泌] R445.2[医药卫生—内科学]