慢性荨麻疹患者血清IL-31水平测定及其临床意义  

The expression and clinical significance of serum IL-31 in patients with chronic urticaria

作　　者：谢华[1] 柴若楠[1] 郑岩[1] 宋薇薇[1] 刘蕾[1] 曾庆为[1] 马壮[1] 陈萍[1] 

机构地区：[1]沈阳军区总医院全军呼吸内科及变态反应疾病诊治中心,辽宁沈阳110016

出　　处：《临床皮肤科杂志》2014年第9期540-542,共3页Journal of Clinical Dermatology

摘　　要：目的:探讨慢性荨麻疹(chronic urticaria,CU)患者血清中白介素(IL)-31水平及其临床意义。方法:采用酶联免疫吸附法(ELISA)检测64例CU患者(其中sIgE阳性和阴性各32例)和32例正常人对照组血清中IL-31水平。结果:CU sIgE(+)组血清IL-31水平均值为(18.8±9.1)ng/L,slgE(-)组为(19.1±7.9)ng/L,分别与正常人对照组比较[(12.9±5.8)ng/L],二组间差异均有统计学意义(P<0.01);CU slgE(+)组中,14例螨虫过敏组患者的IL-31水平均值为(21.4±6.3)ng/L,高于正常人对照组(P<0.05)。结论:CU患者体内IL-31水平升高,可能参与CU发病过程。Objective： To investigate the expression levels of serum IL-31 in patients with chronic urticaria and its clinical significance. Methods： The expression levels of serum IL-31 were detected by enzyme-linked immunoabsorbent assay （ELISA） in 64 chronic urticaria patients [sIgE（＋）32 cases and sIgE（-）32 cases] and 32 normal controls. Results： The levels of serum IL-31 in chronic urticaria were significantly higher than that in normal controls [（18.8±9.1）ng/L in sIgE （＋） and （19.1±7.9）ng/L in sIgE （-） vs. （12.9±5.8）pg/mL in normal controls, P〈0.05 for both]. Among patients with sIgE （＋）, 14 patients with mite allergy also had a significantly higher level of IL-31 [（21.4±6.3）ng/L vs. normal controls, P〈0.01]. Conclusion： The levels of IL-31 are elevated in patients with chronic urticaria and IL-31 may be involved in the pathogenesis of chronic urticaria.

关 键 词：荨麻疹 白介素-31 过敏原 

分 类 号：R758[医药卫生—皮肤病学与性病学]