垂体腺瘤质地及其相关因素分析  

Analysis of pituitary adenoma consistency and its related factors

作　　者：张寒[1] 胡卫星[1] 

机构地区：[1]南京医科大学,江苏省210029

出　　处：《江苏医药》2014年第16期1871-1873,共3页Jiangsu Medical Journal

摘　　要：目的探讨垂体腺瘤质地与相关临床和病理特征的关系。方法由2名影像科医生独立评估30例垂体腺瘤患者的MRI常规序列资料。神经外科医生在术后将病例分为A组(瘤体质地软,22例)和B组(瘤体质地坚韧,8例),采用天狼星红染色检测肿瘤组织中的胶原蛋白。结果垂体腺瘤质地与患者的临床特征如性别、肿瘤大小和生长方式无明显相关。A、B两组瘤体与T1WI白质的信号比相仿(0.8791±0.1078vs.0.8872±0.1023)(P>0.05);但A组瘤体与T2WI白质的信号比大于B组(1.7573±0.2622vs.1.5220±0.1839)(P<0.05)。A组肿瘤组织胶原含量(IPP图像分析系统计算面积百分比)少于B组[(13.210±3.499)%vs.(35.450±8.125)%](P<0.05)。结论T2WI上的垂体腺瘤瘤体白质的信号比与垂体腺瘤质地相关;垂体腺瘤的质地可能与胶原沉积相关。Objective To investigate the association of pituitary adenoma consistency and clinicopathological features.Methods The conventional MRI sequences of 30 cases underwent resection of pituitary adenoma were analyzed separately by two neuroradiologists.The tumors resected were assigned by surgeons into two groups of A（soft tumor,22samples）and B（hard tumor,8samples）.Collagen contents in the tumors were detected by sirius red staining.Results The tumor consistency was not significantly associated to gender,tumor size,and way of growth.The signal ratio of tumor to white matter in T1 weighted MRI（T1WI/TWSIR）in group A was similar to that in group B（0.8791±0.1078 vs.0.8872±0.1023）（P〉0.05）.The signal ratio of the tumor to white matter in T2 weighted MRI（T2WI/TWSIR）was higher in group A than that in group B（1.7573±0.2622 vs.1.5220±0.1839）（P〈0.05）.Collagen content in the tumor was less in group A than that in group B[（13.210±3.499）%vs.（35.450±8.125）%]（P〈0.05）.Conclusion T2WI/TWSIR in the tumor is closely related to the consistency of pituitary adenoma.The consistency of pituitary adenoma may be related to the deposition of collagen in tumors.

关 键 词：垂体瘤 

分 类 号：R651[医药卫生—外科学]