角叉菜胶诱导大鼠前列腺炎及其模型评估  

The Research on Inflammation Marker of Prostatitis Induced by Carrageenan in Rats

作　　者：周莉[1] 骆永伟[1,2] 王永[1] 王蓉[1] 贾玉玲[1,2] 陈颖[1] 刘向云[1] 孙祖越[1] 

机构地区：[1] 上海市计划生育科学研究所药理毒理学研究室,中国生育调节药物毒理检测中心,上海200032 [2]复旦大学药学院,上海201203

出　　处：《实验动物与比较医学》2014年第4期266-271,共6页Laboratory Animal and Comparative Medicine

基　　金：十二五“重大新药创制”科技重大专项（2011ZX09301-005）和上海市实验动物创新行动计划项目（11140901300/11140901303）

摘　　要：目的 通过角叉菜胶诱导SD大鼠化学性前列腺炎,探讨SD大鼠的相关炎症指标的变化,为前列腺炎发生机制和治疗提供一条实验性途径.方法 20只大鼠随机分为两组,阴性对照组和角叉菜胶组各10只.角叉菜胶组用1％λ-角叉菜胶生理盐水溶液0.1 ml直接注射前列腺内,阴性对照组注射生理盐水.造模后31d处死大鼠.结果 在SD大鼠前列腺内注射1％λ-角叉菜胶生理盐水溶液制作的化学性前列腺炎模型中,观察到前列腺间质有中量和少量淋巴细胞和单核细胞浸润,呈现明显的慢性炎症表现.与阴性对照组相比,CRP（C-反应蛋白）含量明显增加（P＜0.05）,睾酮含量升高（P＜0.01）,E2含量降低（P＜0.05）.结论 化学因素引起的慢性非细菌性前列腺炎可导致体内相关炎症指标的改变.Objective To explore the inflammation markers in prostatitis induced by carrageenan in rats. Methods Twenty rats were randomly divided into two groups, negative control group and model group （1% carrageenan）, each group with 10 ones. Model group was injected with 0.1 ml 1% carrageenan physiological saline solution into the prostate. The negative control group was injected with equal dose of physiological saline at the same time and location. Results In model group, there were volume and a small amount of lymphocytes and mononuclear cells infiltration in the prostatic stroma, which showed obvious chronic inflammation. Compared with negative control group, CRP （C-reactive protein） content was significantly increased （P〈0.05） in model group. The level of testosterone was significantly increased （P〈0.01） and estrogen was decreased （P〈0.05）. Conclusion The chronic non-bacterial prostatitis can be induced by carrageenan, and lead to the changes of the inflammation markers, such as CRP, testosterone and estrogen.

关 键 词：化学性前列腺炎 SD大鼠 炎症指标 

分 类 号：R285.5[医药卫生—中药学]