成骨细胞在造血微环境中的作用及与部分血液系统疾病关系的研究进展  

Roles of Osteoblasts in Hematopoietic Stem Cell Niche and Relationship Between Osteoblasts and Hematopoietic Diseases——Review

作　　者：费成明[1] 常春康[1] 

机构地区：[1]上海交通大学附属第六人民医院血液科,上海200233

出　　处：《中国实验血液学杂志》2014年第4期1133-1136,共4页Journal of Experimental Hematology

摘　　要：造血微环境(造血龛)主要由成骨龛和血管龛组成,而成骨细胞是成骨龛的主要组成成分,并对调节造血龛起到重要作用,成骨细胞与多种血液系统疾病密切相关。本文就成骨细胞在造血微环境中的作用以及成骨细胞与部分血液系统疾病关系的最新进展作一综述。Hemopoietic stem cells （HSCs） are regulated by two niches ： osteoblastic niche and vascular niche. Osteo- blasts are the critical constitutive regulators of the osteoblastic niche. The significance of osteoblasts for hematopoietic disease has not escaped attention. This review attempts to capture the discoveries of the last few years regarding the role of osteoblasts in hematopoietic stem cell niche and relationship between osteoblasts and hematopoietic diseases.

关 键 词：造血微环境 成骨细胞 成骨龛 血管龛 造血干细胞 血液系统疾病 

分 类 号：R322.2[医药卫生—人体解剖和组织胚胎学] R331.2[医药卫生—基础医学]