Nrf2出核转运机制及意义的研究进展  

Updated nuclear export mechanism and significance of Nrf2

作　　者：段家翔 甯交琳[1] 鲁开智[1] 

机构地区：[1]第三军医大学附属西南医院手术麻醉科,重庆医学硕士研究400038

出　　处：《医学研究生学报》2014年第8期874-877,共4页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81100055)

摘　　要：核因子E2相关因子2(nuclear factor-E2-related factor 2,Nrf2)是C'n'C转录因子家族成员之一,在各种组织细胞中广泛表达,是细胞调节抗氧化应激反应的重要转录因子。近年来研究发现Nrf2完成抗氧化应激基因诱导后快速降解与其转录激活同样重要,而Nrf2的出核转运是在细胞质中快速降解的前提。文中就目前Nrf2出核转运机制的研究进展作一综述。Nuclear factor-E2-related factor 2 （Nrf2） is a member of C＇n＇C transcription factor family. It is an important transcription factor for regulation of cellular redox status and can be seen in all kinds of tissues. Recent studies have demonstrated that rapid degradation of Nrf2 after gene-induced antioxidative stress is as important as transcription and activation of Nrf2 and the nuclear export of Nrf2 is a prerequisite for rapid degradation of Nrf2 in the cytosol. This review focuses on the mechanism of nuclear export of Nrf2.

关 键 词：核因子E2相关因子2 出核转运 氧化应激 

分 类 号：Q71[生物学—分子生物学]