家畜诱导性多能干细胞研究进展  

Progress in Livestock Induced Pluripotent Stem Cells

作　　者：李嘉宁[1] 刘鹏霞[1] 

机构地区：[1]内蒙古大学生命科学学院国家动物转基因技术研究中心,呼和浩特010021

出　　处：《生物技术通报》2014年第9期28-33,共6页Biotechnology Bulletin

基　　金：国家自然科学基金项目(31101698);内蒙古自治区自然科学基金(2011JQ03);内蒙古大学大学生创新创业训练计划项目(201314204)

摘　　要：目前,家畜胚胎干细胞(Embryonic stem cells,ESCs)建系技术还不完善,很多大型家畜都未能建立ESCs系,这在很大程度上限制了家畜相关研究的开展。诱导性多能干细胞(Induced pluripotent stem cells,iPSCs)技术的建立,为迅速、高效的获得家畜多潜能干细胞提供了新方法。家畜iPSCs的建立,将推动家畜发育生物学、异种器官移植、人类疾病模型建立、家畜品种改良等研究。综述了家畜iPSCs技术的最新进展,并探讨了家畜iPSCs的应用前景。To date, producing functional germline-competent embryonic stem cells（ESCs）has proven to be challenging in most livestocks, like pig, sheep, cattle et al. Induced pluripotent stem cell（iPSC）technique provides a feasible approach to establish pluripotent stem cells for a species in which ESCs have previously proven to be difficult to establish from the early embryo. Livestock iPSCs can offer a route to promote developmental biology research, obtain organs for xenotransplantation, establish animal models for human genetic disease, generate high quality and disease-resistant new breeds et al. The fundamental researches and address the perspectives of livestock iPSCs were reviewed.

关 键 词：家畜育种学 诱导性多能干细胞 胚胎干细胞 

分 类 号：S814.8[农业科学—畜牧学]